Adhesion, Vitality and Osteogenic Differentiation Capacity of Adipose Derived Stem Cells Seeded on Nitinol Nanoparticle Coatings

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dc.identifier.uri Strauß, Sarah Neumeister, Anne Barcikowski, Stephan Kracht, Dietmar Kuhbier, Jörn W. Radtke, Christine Reimers, Kerstin Vogt, Peter M. 2019-03-27T11:25:34Z 2019-03-27T11:25:34Z 2013
dc.identifier.citation Strauß, S.; Neumeister, A.; Barcikowski, S.; Kracht, D.; Kuhbier, J.W. et al.: Adhesion, Vitality and Osteogenic Differentiation Capacity of Adipose Derived Stem Cells Seeded on Nitinol Nanoparticle Coatings. In: PLoS ONE 8 (2013), Nr. 1, e53309. DOI:
dc.description.abstract Autologous cells can be used for a bioactivation of osteoimplants to enhance osseointegration. In this regard, adipose derived stem cells (ASCs) offer interesting perspectives in implantology because they are fast and easy to isolate. However, not all materials licensed for bone implants are equally suited for cell adhesion. Surface modifications are under investigation to promote cytocompatibility and cell growth. The presented study focused on influences of a Nitinol-nanoparticle coating on ASCs. Possible toxic effects as well as influences on the osteogenic differentiation potential of ASCs were evaluated by viability assays, scanning electron microscopy, immunofluorescence and alizarin red staining. It was previously shown that Nitinol-nanoparticles exert no cell toxic effects to ASCs either in soluble form or as surface coating. Here we could demonstrate that a Nitinol-nanoparticle surface coating enhances cell adherence and growth on Nitinol-surfaces. No negative influence on the osteogenic differentiation was observed. Nitinol-nanoparticle coatings offer new possibilities in implantology research regarding bioactivation by autologous ASCs, respectively enhancement of surface attraction to cells. eng
dc.language.iso eng
dc.publisher San Francisco, California, US : PLOS
dc.relation.ispartofseries PLoS ONE 8 (2013), Nr. 1
dc.rights CC BY 3.0 Unported
dc.subject alizarin red s eng
dc.subject nanoparticle eng
dc.subject nitinol eng
dc.subject adipose derived stem cell eng
dc.subject adolescent eng
dc.subject adult eng
dc.subject animal cell eng
dc.subject article eng
dc.subject cell activity eng
dc.subject cell adhesion eng
dc.subject cell assay eng
dc.subject cell death eng
dc.subject cell differentiation eng
dc.subject cell function eng
dc.subject cell viability eng
dc.subject concentration (parameters) eng
dc.subject controlled study eng
dc.subject female eng
dc.subject human eng
dc.subject human cell eng
dc.subject immunofluorescence eng
dc.subject immunohistochemistry eng
dc.subject male eng
dc.subject material coating eng
dc.subject mouse eng
dc.subject nonhuman eng
dc.subject particle size eng
dc.subject scanning electron microscopy eng
dc.subject surface property eng
dc.subject Adipose Tissue eng
dc.subject Alloys eng
dc.subject Animals eng
dc.subject Cell Adhesion eng
dc.subject Cell Differentiation eng
dc.subject Cell Line eng
dc.subject Cell Proliferation eng
dc.subject Cells, Cultured eng
dc.subject Coated Materials, Biocompatible eng
dc.subject Humans eng
dc.subject Mice eng
dc.subject Nanoparticles eng
dc.subject Osteogenesis eng
dc.subject Stem Cells eng
dc.subject Tissue Scaffolds eng
dc.subject.ddc 500 | Naturwissenschaften ger
dc.subject.ddc 610 | Medizin, Gesundheit ger
dc.title Adhesion, Vitality and Osteogenic Differentiation Capacity of Adipose Derived Stem Cells Seeded on Nitinol Nanoparticle Coatings
dc.type Article
dc.type Text
dc.relation.issn 1932-6203
dc.bibliographicCitation.issue 1
dc.bibliographicCitation.volume 8
dc.bibliographicCitation.firstPage e53309
dc.description.version publishedVersion
tib.accessRights frei zug�nglich

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    Frei zugängliche Publikationen aus An-Instituten der Leibniz Universität Hannover

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