Hydrogels for efficient light delivery in optogenetic applications

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dc.identifier.uri http://dx.doi.org/10.15488/3834
dc.identifier.uri https://www.repo.uni-hannover.de/handle/123456789/3868
dc.contributor.author Johannsmeier, S.
dc.contributor.author Torres, M.L.
dc.contributor.author Ripken, T.
dc.contributor.author Heinemann, D.
dc.contributor.author Heisterkamp, Alexander
dc.date.accessioned 2018-10-11T08:42:11Z
dc.date.available 2018-10-11T08:42:11Z
dc.date.issued 2018
dc.identifier.citation Johannsmeier, S.; Torres, M.L.; Ripken, T.; Heinemann, D.; Heisterkamp, A.: Hydrogels for efficient light delivery in optogenetic applications. In: Proceedings of SPIE - The International Society for Optical Engineering 10482 (2018), 104820Q. DOI: https://doi.org/10.1117/12.2289470
dc.description.abstract Light-based therapies have been established for various indications, such as skin conditions, cancer or neonatal jaundice. Advances in the field of optogenetics open up new horizons for light-tissue interactions with an organism-wide impact. Excitable tissues, such as nerve and muscle tissues, can be controlled by light after the introduction of light-sensitive ion channels. Since these organs are generally not easily accessible to illumination in vivo, there is an increasing need for effective biocompatible waveguides for light delivery. These devices not only have to guide and distribute the light as desired with minimal losses, they should also mimic the mechanical properties of the surrounding tissue to ensure compatibility. In this project, we are tuning the properties of hydrogels from poly(ethylene glycol) derivatives to achieve compatibility with muscle tissue as well as optimal light guiding and distribution for optogenetic applications at the heart. The excitation light is coupled into the hydrogel with a biocompatible fiber. Properties of the hydrogel are mainly tuned by monomer length and concentration. Total reflection can be achieved by embedding a fiber-like hydrogel with a high refractive index into a second, low refractive index gel. Different geometries and scattering microparticles are used for light distribution in a flat gel patch. Targeted cell attachment can be achieved by introducing a protein layer to the otherwise bioinert gel. After optimization, the hydrogel may be used to deliver light for the excitation of genetically altered cardiomyocytes for controlled contraction. eng
dc.language.iso eng
dc.publisher Bellingham, WA : SPIE - International Society for Optical Engineering
dc.relation.ispartofseries Proceedings of SPIE - The International Society for Optical Engineering 10482 (2018)
dc.rights Es gilt deutsches Urheberrecht. Das Dokument darf zum eigenen Gebrauch kostenfrei genutzt, aber nicht im Internet bereitgestellt oder an Außenstehende weitergegeben werden. Dieser Beitrag ist aufgrund einer (DFG-geförderten) Allianz- bzw. Nationallizenz frei zugänglich. ger
dc.subject Biohybrid implant eng
dc.subject Cardiac pacing eng
dc.subject Defibrillation eng
dc.subject Hydrogels eng
dc.subject Light delivery eng
dc.subject Optogenetics eng
dc.subject Waveguiding eng
dc.subject Biocompatibility eng
dc.subject Biomechanics eng
dc.subject Histology eng
dc.subject Muscle eng
dc.subject Polyethylene glycols eng
dc.subject Refractive index eng
dc.subject Waveguides eng
dc.subject Cardiac pacing eng
dc.subject Defibrillation eng
dc.subject Light delivery eng
dc.subject Optogenetics eng
dc.subject Waveguiding eng
dc.subject Hydrogels eng
dc.subject.classification Konferenzschrift ger
dc.subject.ddc 600 | Technik ger
dc.title Hydrogels for efficient light delivery in optogenetic applications
dc.type article
dc.type Text
dc.relation.issn 16057422
dc.relation.doi https://doi.org/10.1117/12.2289470
dc.bibliographicCitation.volume 10482
dc.bibliographicCitation.firstPage 104820Q
dc.description.version publishedVersion
tib.accessRights frei zug�nglich


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