Hydrogels for efficient light delivery in optogenetic applications

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Johannsmeier, S.; Torres, M.L.; Ripken, T.; Heinemann, D.; Heisterkamp, A.: Hydrogels for efficient light delivery in optogenetic applications. In: Proceedings of SPIE - The International Society for Optical Engineering 10482 (2018), 104820Q. DOI: https://doi.org/10.1117/12.2289470

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Sum total of downloads: 193

Light-based therapies have been established for various indications, such as skin conditions, cancer or neonatal jaundice. Advances in the field of optogenetics open up new horizons for light-tissue interactions with an organism-wide impact. Excitable tissues, such as nerve and muscle tissues, can be controlled by light after the introduction of light-sensitive ion channels. Since these organs are generally not easily accessible to illumination in vivo, there is an increasing need for effective biocompatible waveguides for light delivery. These devices not only have to guide and distribute the light as desired with minimal losses, they should also mimic the mechanical properties of the surrounding tissue to ensure compatibility. In this project, we are tuning the properties of hydrogels from poly(ethylene glycol) derivatives to achieve compatibility with muscle tissue as well as optimal light guiding and distribution for optogenetic applications at the heart. The excitation light is coupled into the hydrogel with a biocompatible fiber. Properties of the hydrogel are mainly tuned by monomer length and concentration. Total reflection can be achieved by embedding a fiber-like hydrogel with a high refractive index into a second, low refractive index gel. Different geometries and scattering microparticles are used for light distribution in a flat gel patch. Targeted cell attachment can be achieved by introducing a protein layer to the otherwise bioinert gel. After optimization, the hydrogel may be used to deliver light for the excitation of genetically altered cardiomyocytes for controlled contraction.
License of this version: Es gilt deutsches Urheberrecht. Das Dokument darf zum eigenen Gebrauch kostenfrei genutzt, aber nicht im Internet bereitgestellt oder an Außenstehende weitergegeben werden. Dieser Beitrag ist aufgrund einer (DFG-geförderten) Allianz- bzw. Nationallizenz frei zugänglich.
Document Type: article
Publishing status: publishedVersion
Issue Date: 2018
Appears in Collections:An-Institute

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pos. country downloads
total perc.
1 image of flag of Germany Germany 151 78.24%
2 image of flag of United States United States 12 6.22%
3 image of flag of China China 5 2.59%
4 image of flag of Singapore Singapore 4 2.07%
5 image of flag of Turkey Turkey 3 1.55%
6 image of flag of Russian Federation Russian Federation 3 1.55%
7 image of flag of Korea, Republic of Korea, Republic of 3 1.55%
8 image of flag of France France 2 1.04%
9 image of flag of Czech Republic Czech Republic 2 1.04%
10 image of flag of Canada Canada 2 1.04%
    other countries 6 3.11%

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