Study of Protein Adsorption During Sterile Filtration of Protein Formulations by ILC

Originalpublikation

Haindl, S.M.H.; Doppleb, O.; Förster, L.; Wraage, S.; Reiche, A.: Study of Protein Adsorption During Sterile Filtration of Protein Formulations by ILC. In: Chemie-Ingenieur-Technik 92 (2020), Nr. 8, S. 1109-1121. DOI: https://doi.org/10.1002/cite.201900185

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Zusammenfassung:
Protein adsorption is usually regarded as the main reason for filter fouling in sterile filtration of protein formulations. To achieve a better insight into this phenomenon, protein adsorption was studied during filtration of stabilized bovine serum albumin (BSA) and γ‐globulin formulations through 0.2-µm microfilter membranes by inverse liquid chromatography (ILC). Adsorption processes can be studied with this method by measurement of breakthrough curves. The change of the concentration in the fluid phase is measured with high accuracy by an inline UV-detector. © 2020 The Authors. Published by WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Lizenzbestimmungen: CC BY 4.0 Unported - https://creativecommons.org/licenses/by/4.0/
Publikationstyp: Article
Publikationsstatus: publishedVersion
Erstveröffentlichung: 2020
Schlagwörter (englisch): inverse liquid chromatography, protein adsorption, sterile filtration
Fachliche Zuordnung (DDC): 540 | Chemie

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