Orange, red, yellow: Biosynthesis of azaphilone pigments in Monascus fungi

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Chen, W.; Chen, R.; Liu, Q.; He, Y.; He, K. et al.: Orange, red, yellow: Biosynthesis of azaphilone pigments in Monascus fungi. In: Chemical Science 8 (2017), Nr. 7, S. 4917-4925. DOI:

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Sum total of downloads: 237

Monascus azaphilone pigments (MonAzPs) are very widely used as food colorants, but their biosynthetic pathway has remained poorly characterized for more than half a century. In this study, the individual steps of MonAzPs biosynthesis in Monascus ruber M7 were elucidated by a combination of targeted gene knockouts, heterologous gene expression, and in vitro chemical and enzymatic reactions. This study describes the first rational engineering of MonAzPs biosynthesis and provides a roadmap for future pathway engineering efforts directed towards the selective production of the most valuable pigments and serves as a model for the biosynthesis of fungal azaphilones in general.
License of this version: CC BY-NC 3.0 Unported
Document Type: Article
Publishing status: publishedVersion
Issue Date: 2017
Appears in Collections:Naturwissenschaftliche Fakultät

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pos. country downloads
total perc.
1 image of flag of Germany Germany 104 43.88%
2 image of flag of United States United States 57 24.05%
3 image of flag of China China 23 9.70%
4 image of flag of No geo information available No geo information available 7 2.95%
5 image of flag of Italy Italy 5 2.11%
6 image of flag of France France 5 2.11%
7 image of flag of Japan Japan 4 1.69%
8 image of flag of Poland Poland 3 1.27%
9 image of flag of Ireland Ireland 3 1.27%
10 image of flag of Denmark Denmark 3 1.27%
    other countries 23 9.70%

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