Abstract: |
This paper describes a method for comparisons of several treatments with a control, simultaneously for multiple endpoints. These endpoints are assumed to be normally distributed with different scales and variances. An approximate multivariate t-distribution is used to obtain quantiles for test decisions, multiplicity-adjusted p-values, and simultaneous confidence intervals. Simulation results show that this approach controls the family-wise error type I over both the comparisons and the endpoints in an admissible range. The approach will be applied to a randomized clinical trial comparing two new sets of extracorporeal circulations with a standard for three primary endpoints. A related R package is available. © 2011 Berkeley Electronic Press. All rights reserved.
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License of this version: |
Es gilt deutsches Urheberrecht. Das Dokument darf zum eigenen Gebrauch kostenfrei genutzt, aber nicht im Internet bereitgestellt oder an Außenstehende weitergegeben werden. Dieser Beitrag ist aufgrund einer (DFG-geförderten) Allianz- bzw. Nationallizenz frei zugänglich. |
Publication type: |
Article |
Publishing status: |
publishedVersion |
Publication date: |
2011 |
Keywords english: |
family-wise error, many-to-one comparison, multiple endpoints, multivariate <em>t</ em>-distribution, article, binomial distribution, dunnett procedure, extracorporeal circulation, multiple endpoint, multivariate analysis, rating scale, simulation, statistical analysis, variance
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DDC: |
570 | Biowissenschaften, Biologie
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