dc.identifier.uri |
http://dx.doi.org/10.15488/2285 |
|
dc.identifier.uri |
http://www.repo.uni-hannover.de/handle/123456789/2311 |
|
dc.contributor.author |
Hasler, Mario
|
|
dc.contributor.author |
Hothorn, Ludwig A.
|
|
dc.date.accessioned |
2017-11-17T08:10:19Z |
|
dc.date.available |
2017-11-17T08:10:19Z |
|
dc.date.issued |
2011 |
|
dc.identifier.citation |
Hasler, M.; Hothorn, L.A.: A dunnett-type procedure for multiple endpoints. In: International Journal of Biostatistics 7 (2011), Nr. 1, 3. DOI: https://doi.org/10.2202/1557-4679.1258 |
|
dc.description.abstract |
This paper describes a method for comparisons of several treatments with a control, simultaneously for multiple endpoints. These endpoints are assumed to be normally distributed with different scales and variances. An approximate multivariate t-distribution is used to obtain quantiles for test decisions, multiplicity-adjusted p-values, and simultaneous confidence intervals. Simulation results show that this approach controls the family-wise error type I over both the comparisons and the endpoints in an admissible range. The approach will be applied to a randomized clinical trial comparing two new sets of extracorporeal circulations with a standard for three primary endpoints. A related R package is available. © 2011 Berkeley Electronic Press. All rights reserved. |
eng |
dc.language.iso |
eng |
|
dc.publisher |
Berlin : Walter de Gruyter |
|
dc.relation.ispartofseries |
International Journal of Biostatistics 7 (2011), Nr. 1 |
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dc.rights |
Es gilt deutsches Urheberrecht. Das Dokument darf zum eigenen Gebrauch kostenfrei genutzt, aber nicht im Internet bereitgestellt oder an Außenstehende weitergegeben werden. Dieser Beitrag ist aufgrund einer (DFG-geförderten) Allianz- bzw. Nationallizenz frei zugänglich. |
|
dc.subject |
family-wise error |
eng |
dc.subject |
many-to-one comparison |
eng |
dc.subject |
multiple endpoints |
eng |
dc.subject |
multivariate <em>t</ em>-distribution |
eng |
dc.subject |
article |
eng |
dc.subject |
binomial distribution |
eng |
dc.subject |
dunnett procedure |
eng |
dc.subject |
extracorporeal circulation |
eng |
dc.subject |
multiple endpoint |
eng |
dc.subject |
multivariate analysis |
eng |
dc.subject |
rating scale |
eng |
dc.subject |
simulation |
eng |
dc.subject |
statistical analysis |
eng |
dc.subject |
variance |
eng |
dc.subject.ddc |
570 | Biowissenschaften, Biologie
|
ger |
dc.title |
A dunnett-type procedure for multiple endpoints |
eng |
dc.type |
Article |
|
dc.type |
Text |
|
dc.relation.issn |
1557-4679 |
|
dc.relation.doi |
https://doi.org/10.2202/1557-4679.1258 |
|
dc.bibliographicCitation.issue |
1 |
|
dc.bibliographicCitation.volume |
7 |
|
dc.bibliographicCitation.firstPage |
3 |
|
dc.description.version |
publishedVersion |
|
tib.accessRights |
frei zug�nglich |
|