A practical synthesis of Rho-Kinase inhibitor Y-27632 and fluoro derivatives and their evaluation in human pluripotent stem cells

Paleek, Jiri; Zweigerdt, Robert; Olmer, Ruth; Martin, Ulrich; Kirschning, Andreas; Dräger, Gerald

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Paleek, J.; Zweigerdt, R.; Olmer, R.; Martin, U.; Kirschning, A. et al.: A practical synthesis of Rho-Kinase inhibitor Y-27632 and fluoro derivatives and their evaluation in human pluripotent stem cells. In: Organic and Biomolecular Chemistry 9 (2011), Nr. 15, S. 5503-5510. DOI: https://doi.org/10.1039/c1ob05332a

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To cite the version in the repository, please use this identifier: https://doi.org/10.15488/2155

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Abstract:
A practical synthesis of the Rho-Kinase inhibitor Y-27632 and two new fluoro derivatives was achieved in seven steps and with a good overall yield of 45% starting from commercially available (R)-1-phenylethylamine. Compared to Y-27632 the new fluoro derivatives showed reduced or no effect on hPSC vitality and expansion after dissociation in human pluripotent stem cells. © 2011 The Royal Society of Chemistry.
License of this version:	Es gilt deutsches Urheberrecht. Das Dokument darf zum eigenen Gebrauch kostenfrei genutzt, aber nicht im Internet bereitgestellt oder an Außenstehende weitergegeben werden. Dieser Beitrag ist aufgrund einer (DFG-geförderten) Allianz- bzw. Nationallizenz frei zugänglich.
Publication type:	Article
Publishing status:	publishedVersion
Publication date:	2011
Keywords english:	Phenylethylamines, Pluripotent stem cells, Rho-kinase inhibitors, Enzymes, Stem cells, 4 (1 aminoethyl) n (4 pyridyl)cyclohexanecarboxamide, amide, enzyme inhibitor, fluorine, pyridine derivative, Rho kinase, article, cell culture, cell proliferation, chemical structure, chemistry, drug antagonism, drug effect, human, nuclear magnetic resonance spectroscopy, pluripotent stem cell, synthesis, Amides, Cell Proliferation, Cells, Cultured, Enzyme Inhibitors, Fluorine, Humans, Magnetic Resonance Spectroscopy, Molecular Structure, Pluripotent Stem Cells, Pyridines, rho-Associated Kinases
DDC:	540 \| Chemie