A practical synthesis of Rho-Kinase inhibitor Y-27632 and fluoro derivatives and their evaluation in human pluripotent stem cells

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dc.identifier.uri http://dx.doi.org/10.15488/2155
dc.identifier.uri http://www.repo.uni-hannover.de/handle/123456789/2180
dc.contributor.author Paleek, Jiri
dc.contributor.author Zweigerdt, Robert
dc.contributor.author Olmer, Ruth
dc.contributor.author Martin, Ulrich
dc.contributor.author Kirschning, Andreas
dc.contributor.author Dräger, Gerald
dc.date.accessioned 2017-10-30T13:12:53Z
dc.date.available 2017-10-30T13:12:53Z
dc.date.issued 2011
dc.identifier.citation Paleek, J.; Zweigerdt, R.; Olmer, R.; Martin, U.; Kirschning, A. et al.: A practical synthesis of Rho-Kinase inhibitor Y-27632 and fluoro derivatives and their evaluation in human pluripotent stem cells. In: Organic and Biomolecular Chemistry 9 (2011), Nr. 15, S. 5503-5510. DOI: https://doi.org/10.1039/c1ob05332a
dc.description.abstract A practical synthesis of the Rho-Kinase inhibitor Y-27632 and two new fluoro derivatives was achieved in seven steps and with a good overall yield of 45% starting from commercially available (R)-1-phenylethylamine. Compared to Y-27632 the new fluoro derivatives showed reduced or no effect on hPSC vitality and expansion after dissociation in human pluripotent stem cells. © 2011 The Royal Society of Chemistry. eng
dc.language.iso eng
dc.publisher Cambridge : Royal Society of Chemistry
dc.relation.ispartofseries Organic and Biomolecular Chemistry 9 (2011), Nr. 15
dc.rights Es gilt deutsches Urheberrecht. Das Dokument darf zum eigenen Gebrauch kostenfrei genutzt, aber nicht im Internet bereitgestellt oder an Außenstehende weitergegeben werden. Dieser Beitrag ist aufgrund einer (DFG-geförderten) Allianz- bzw. Nationallizenz frei zugänglich.
dc.subject Phenylethylamines eng
dc.subject Pluripotent stem cells eng
dc.subject Rho-kinase inhibitors eng
dc.subject Enzymes eng
dc.subject Stem cells eng
dc.subject 4 (1 aminoethyl) n (4 pyridyl)cyclohexanecarboxamide eng
dc.subject amide eng
dc.subject enzyme inhibitor eng
dc.subject fluorine eng
dc.subject pyridine derivative eng
dc.subject Rho kinase eng
dc.subject article eng
dc.subject cell culture eng
dc.subject cell proliferation eng
dc.subject chemical structure eng
dc.subject chemistry eng
dc.subject drug antagonism eng
dc.subject drug effect eng
dc.subject human eng
dc.subject nuclear magnetic resonance spectroscopy eng
dc.subject pluripotent stem cell eng
dc.subject synthesis eng
dc.subject Amides eng
dc.subject Cell Proliferation eng
dc.subject Cells, Cultured eng
dc.subject Enzyme Inhibitors eng
dc.subject Fluorine eng
dc.subject Humans eng
dc.subject Magnetic Resonance Spectroscopy eng
dc.subject Molecular Structure eng
dc.subject Pluripotent Stem Cells eng
dc.subject Pyridines eng
dc.subject rho-Associated Kinases eng
dc.subject.ddc 540 | Chemie ger
dc.title A practical synthesis of Rho-Kinase inhibitor Y-27632 and fluoro derivatives and their evaluation in human pluripotent stem cells eng
dc.type Article
dc.type Text
dc.relation.issn 1477-0520
dc.relation.doi https://doi.org/10.1039/c1ob05332a
dc.bibliographicCitation.issue 15
dc.bibliographicCitation.volume 9
dc.bibliographicCitation.firstPage 5503
dc.bibliographicCitation.lastPage 5510
dc.description.version publishedVersion
tib.accessRights frei zug�nglich


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