A novel shape memory plate osteosynthesis for noninvasive modulation of fixation stiffness in a rabbit tibia osteotomy model

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dc.identifier.uri http://dx.doi.org/10.15488/4574
dc.identifier.uri https://www.repo.uni-hannover.de/handle/123456789/4616
dc.contributor.author Müller, Christian W.
dc.contributor.author Pfeifer, Ronny
dc.contributor.author Meier, Karen
dc.contributor.author Decker, Sebastian
dc.contributor.author Reifenrath, Janin
dc.contributor.author Gösling, Thomas
dc.contributor.author Wesling, Volker
dc.contributor.author Krettek, Christian
dc.contributor.author Hurschler, Christof
dc.contributor.author Krämer, Manuel
dc.date.accessioned 2019-03-27T11:25:34Z
dc.date.available 2019-03-27T11:25:34Z
dc.date.issued 2015
dc.identifier.citation Muller, C.W.; Pfeifer, R.; Meier, K.; Decker, S.; Reifenrath, J. et al.: A novel shape memory plate osteosynthesis for noninvasive modulation of fixation stiffness in a rabbit tibia osteotomy model. In: BioMed Research International 2015 (2015), 652940. DOI: https://doi.org/10.1155/2015/652940
dc.description.abstract Nickel-titanium shape memory alloy (NiTi-SMA) implants might allow modulating fracture healing, changing their stiffness through alteration of both elastic modulus and cross-sectional shape by employing the shape memory effect (SME). Hypotheses: a novel NiTi-SMA plate stabilizes tibia osteotomies in rabbits. After noninvasive electromagnetic induction heating the alloy exhibits the SME and the plate changes towards higher stiffness (inverse dynamization) resulting in increased fixation stiffness and equal or better bony healing. In 14 rabbits, 1.0 mm tibia osteotomies were fixed with our experimental plate. Animals were randomised for control or induction heating at three weeks postoperatively. Repetitive X-ray imaging and in vivo measurements of bending stiffness were performed. After sacrifice at 8 weeks, macroscopic evaluation, μCT, and post mortem bending tests of the tibiae were carried out. One death and one early implant dislocation occurred. Following electromagnetic induction heating, radiographic and macroscopic changes of the implant proved successful SME activation. All osteotomies healed. In the treatment group, bending stiffness increased over time. Differences between groups were not significant. In conclusion, we demonstrated successful healing of rabbit tibia osteotomies using our novel NiTi-SMA plate. We demonstrated shape-changing SME in-vivo through transcutaneous electromagnetic induction heating. Thus, future orthopaedic implants could be modified without additional surgery. eng
dc.language.iso eng
dc.publisher New York, NY : Hindawi Publishing Corporation
dc.relation.ispartofseries BioMed Research International 2015 (2015)
dc.rights CC BY 3.0 Unported
dc.rights.uri https://creativecommons.org/licenses/by/3.0/
dc.subject nickel eng
dc.subject titanium eng
dc.subject biomaterial eng
dc.subject nickel eng
dc.subject titanium eng
dc.subject titanium nickelide eng
dc.subject adult eng
dc.subject animal experiment eng
dc.subject animal model eng
dc.subject Article eng
dc.subject body temperature eng
dc.subject bone mass eng
dc.subject bone plate eng
dc.subject controlled study eng
dc.subject fracture healing eng
dc.subject in vitro study eng
dc.subject male eng
dc.subject nickel titanium shape memory alloy implant eng
dc.subject nonhuman eng
dc.subject osteotomy eng
dc.subject plate fixation eng
dc.subject rabbit model eng
dc.subject radiography eng
dc.subject randomized controlled trial eng
dc.subject rigidity eng
dc.subject shape memory effect eng
dc.subject temperature measurement eng
dc.subject tibia osteotomy eng
dc.subject wound closure eng
dc.subject Young modulus eng
dc.subject animal eng
dc.subject chemistry eng
dc.subject devices eng
dc.subject diagnostic imaging eng
dc.subject disease model eng
dc.subject osteosynthesis eng
dc.subject procedures eng
dc.subject rabbit eng
dc.subject surgery eng
dc.subject tibia eng
dc.subject Animalia eng
dc.subject Oryctolagus cuniculus eng
dc.subject Animals eng
dc.subject Biocompatible Materials eng
dc.subject Bone Plates eng
dc.subject Disease Models, Animal eng
dc.subject Fracture Fixation, Internal eng
dc.subject Male eng
dc.subject Nickel eng
dc.subject Osteotomy eng
dc.subject Rabbits eng
dc.subject Radiography eng
dc.subject Tibia eng
dc.subject Titanium eng
dc.subject.ddc 610 | Medizin, Gesundheit ger
dc.subject.ddc 570 | Biowissenschaften, Biologie ger
dc.title A novel shape memory plate osteosynthesis for noninvasive modulation of fixation stiffness in a rabbit tibia osteotomy model
dc.type Article
dc.type Text
dc.relation.issn 2314-6133
dc.relation.doi https://doi.org/10.1155/2015/652940
dc.bibliographicCitation.volume 2015
dc.bibliographicCitation.firstPage 652940
dc.description.version publishedVersion
tib.accessRights frei zug�nglich

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