Characterisation of the biosynthetic pathway to agnestins A and B reveals the reductive route to chrysophanol in fungi

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dc.identifier.uri http://dx.doi.org/10.15488/4291
dc.identifier.uri https://www.repo.uni-hannover.de/handle/123456789/4325
dc.contributor.author Szwalbe, Agniezka J.
dc.contributor.author Williams, Katherine
dc.contributor.author Song, Zhongshu
dc.contributor.author De Mattos-Shipley, Kate M.J.
dc.contributor.author Vincent, Jason L.
dc.contributor.author Bailey, Andrew M.
dc.contributor.author Willis, Christine L.
dc.contributor.author Cox, Russell J.
dc.contributor.author Simpson, Thomas J.
dc.date.accessioned 2019-01-11T08:57:40Z
dc.date.available 2019-01-11T08:57:40Z
dc.date.issued 2019
dc.identifier.citation Szwalbe, A.J.; Williams, K.; Song, Z.; De Mattos-Shipley, K.; Vincent, J. et al.: Characterisation of the biosynthetic pathway to agnestins A and B reveals the reductive route to chrysophanol in fungi. In: Chemical Science 10 (2019), Nr. 1, S. 233-238. DOI: https://doi.org/10.1039/C8SC03778G
dc.description.abstract Two new dihydroxy-xanthone metabolites, agnestins A and B, were isolated from Paecilomyces variotii along with a number of related benzophenones and xanthones including monodictyphenone. The structures were elucidated by NMR analyses and X-ray crystallography. The agnestin (agn) biosynthetic gene cluster was identified and targeted gene disruptions of the PKS, Baeyer-Villiger monooxygenase, and other oxido-reductase genes revealed new details of fungal xanthone biosynthesis. In particular, identification of a reductase responsible for in vivo anthraquinone to anthrol conversion confirms a previously postulated essential step in aromatic deoxygenation of anthraquinones, e.g. emodin to chrysophanol. eng
dc.language.iso eng
dc.publisher Cambridge : Royal Society of Chemistry
dc.relation.ispartofseries Chemical Science 10 (2019), Nr. 1
dc.rights CC BY 3.0
dc.rights.uri https://creativecommons.org/licenses/by/3.0/
dc.subject Aromatic compounds eng
dc.subject Biochemistry eng
dc.subject Biosynthesis eng
dc.subject Genes eng
dc.subject Ketones eng
dc.subject Baeyer-Villiger monooxygenases eng
dc.subject Biosynthetic gene cluster eng
dc.subject Biosynthetic pathway eng
dc.subject Deoxygenations eng
dc.subject Gene disruptions eng
dc.subject NMR analysis eng
dc.subject Oxido-reductases eng
dc.subject Paecilomyces variotii eng
dc.subject X ray crystallography eng
dc.subject.ddc 540 | Chemie ger
dc.title Characterisation of the biosynthetic pathway to agnestins A and B reveals the reductive route to chrysophanol in fungi
dc.type article
dc.type Text
dc.relation.issn 2041-6520
dc.relation.doi https://doi.org/10.1039/C8SC03778G
dc.bibliographicCitation.issue 1
dc.bibliographicCitation.volume 10
dc.bibliographicCitation.firstPage 233
dc.bibliographicCitation.lastPage 238
dc.description.version publishedVersion
tib.accessRights frei zug�nglich


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