Characterisation of the biosynthetic pathway to agnestins A and B reveals the reductive route to chrysophanol in fungi

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Szwalbe, A.J.; Williams, K.; Song, Z.; De Mattos-Shipley, K.; Vincent, J. et al.: Characterisation of the biosynthetic pathway to agnestins A and B reveals the reductive route to chrysophanol in fungi. In: Chemical Science 10 (2019), Nr. 1, S. 233-238. DOI: https://doi.org/10.1039/C8SC03778G

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Abstract: 
Two new dihydroxy-xanthone metabolites, agnestins A and B, were isolated from Paecilomyces variotii along with a number of related benzophenones and xanthones including monodictyphenone. The structures were elucidated by NMR analyses and X-ray crystallography. The agnestin (agn) biosynthetic gene cluster was identified and targeted gene disruptions of the PKS, Baeyer-Villiger monooxygenase, and other oxido-reductase genes revealed new details of fungal xanthone biosynthesis. In particular, identification of a reductase responsible for in vivo anthraquinone to anthrol conversion confirms a previously postulated essential step in aromatic deoxygenation of anthraquinones, e.g. emodin to chrysophanol.
License of this version: CC BY 3.0 Unported
Document Type: article
Publishing status: publishedVersion
Issue Date: 2019
Appears in Collections:Naturwissenschaftliche Fakultät

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1 image of flag of Germany Germany 54 76.06%
2 image of flag of United States United States 5 7.04%
3 image of flag of China China 4 5.63%
4 image of flag of Denmark Denmark 3 4.23%
5 image of flag of Korea, Republic of Korea, Republic of 1 1.41%
6 image of flag of Italy Italy 1 1.41%
7 image of flag of United Kingdom United Kingdom 1 1.41%
8 image of flag of Brazil Brazil 1 1.41%
9 image of flag of Austria Austria 1 1.41%

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