Classic fungal natural products in the genomic age: The molecular legacy of Harold Raistrick

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dc.identifier.uri http://dx.doi.org/10.15488/3311
dc.identifier.uri http://www.repo.uni-hannover.de/handle/123456789/3341
dc.contributor.author Schor, Raissa
dc.contributor.author Cox, Russell J.
dc.date.accessioned 2018-05-18T09:47:45Z
dc.date.available 2018-05-18T09:47:45Z
dc.date.issued 2018
dc.identifier.citation Schor, Raissa; Cox, Russel: Classic fungal natural products in the genomic age: The molecular legacy of Harold Raistrick. In: Natural Product Reports 35 (2018), Nr. 3, S. 230-256. DOI: https://doi.org/10.1039/c8np00021b
dc.description.abstract Covering: 1893 to 2017 Harold Raistrick was involved in the discovery of many of the most important classes of fungal metabolites during the 20th century. This review focusses on how these discoveries led to developments in isotopic labelling, biomimetic chemistry and the discovery, analysis and exploitation of biosynthetic gene clusters for major classes of fungal metabolites including: alternariol; geodin and metabolites of the emodin pathway; maleidrides; citrinin and the azaphilones; dehydrocurvularin; mycophenolic acid; and the tropolones. Key recent advances in the molecular understanding of these important pathways, including the discovery of biosynthetic gene clusters, the investigation of the molecular and chemical aspects of key biosynthetic steps, and the reengineering of key components of the pathways are reviewed and compared. Finally, discussion of key relationships between metabolites and pathways and the most important recent advances and opportunities for future research directions are given. © 2018 The Royal Society of Chemistry. eng
dc.language.iso eng
dc.publisher Cambridge : Royal Society of Chemistry
dc.relation.ispartofseries Natural Product Reports 35 (2018), Nr. 3
dc.rights CC BY-NC 3.0 Unported
dc.rights.uri https://creativecommons.org/licenses/by-nc/3.0/
dc.subject Harold Raistrick eng
dc.subject Alternariol eng
dc.subject Geodin, ravenelin and the emodin pathway eng
dc.subject Griseofulvin eng
dc.subject Mycophenolic acid eng
dc.subject.ddc 540 | Chemie ger
dc.title Classic fungal natural products in the genomic age: The molecular legacy of Harold Raistrick eng
dc.type article
dc.type Text
dc.relation.issn 0265-0568
dc.relation.doi https://doi.org/10.1039/c8np00021b
dc.bibliographicCitation.issue 3
dc.bibliographicCitation.volume 35
dc.bibliographicCitation.firstPage 230
dc.bibliographicCitation.lastPage 256
dc.description.version publishedVersion
tib.accessRights frei zug�nglich


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