Classic fungal natural products in the genomic age: The molecular legacy of Harold Raistrick

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Schor, Raissa; Cox, Russel: Classic fungal natural products in the genomic age: The molecular legacy of Harold Raistrick. In: Natural Product Reports 35 (2018), Nr. 3, S. 230-256. DOI: https://doi.org/10.1039/c8np00021b

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Sum total of downloads: 166




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Covering: 1893 to 2017 Harold Raistrick was involved in the discovery of many of the most important classes of fungal metabolites during the 20th century. This review focusses on how these discoveries led to developments in isotopic labelling, biomimetic chemistry and the discovery, analysis and exploitation of biosynthetic gene clusters for major classes of fungal metabolites including: alternariol; geodin and metabolites of the emodin pathway; maleidrides; citrinin and the azaphilones; dehydrocurvularin; mycophenolic acid; and the tropolones. Key recent advances in the molecular understanding of these important pathways, including the discovery of biosynthetic gene clusters, the investigation of the molecular and chemical aspects of key biosynthetic steps, and the reengineering of key components of the pathways are reviewed and compared. Finally, discussion of key relationships between metabolites and pathways and the most important recent advances and opportunities for future research directions are given. © 2018 The Royal Society of Chemistry.
License of this version: CC BY-NC 3.0 Unported
Document Type: article
Publishing status: publishedVersion
Issue Date: 2018
Appears in Collections:Naturwissenschaftliche Fakultät

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pos. country downloads
total perc.
1 image of flag of Germany Germany 134 80.72%
2 image of flag of China China 14 8.43%
3 image of flag of United Kingdom United Kingdom 7 4.22%
4 image of flag of United States United States 4 2.41%
5 image of flag of Ireland Ireland 2 1.20%
6 image of flag of Hong Kong Hong Kong 2 1.20%
7 image of flag of Kenya Kenya 1 0.60%
8 image of flag of Iran, Islamic Republic of Iran, Islamic Republic of 1 0.60%
9 image of flag of Switzerland Switzerland 1 0.60%

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