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Original version
Schor, Raissa: Biosynthesis of Xenovulenes in Acremonium strictum. Hannover : Gottfried Wilhelm Leibniz Universität, Diss., 2018, viii, 208 S. DOI: https://doi.org/10.15488/3173
Xenovulenes are a family of fungal meroterpenoids produced by the ascomycete Acremonium strictum. Xenovulene A binds the GABA receptor in vitro. The compound exhibits an unusual tetrahydrofuro-cyclopentenone attached to a humulene ring, which aroused interest in its biosynthesis. In a combined genetic and chemical approach, the biosynthesis of xenovulene A and its co-metabolites was investigated in this work.
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