Experimental middle ear surgery in rabbits: A new approach for reconstructing the ossicular chain

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dc.identifier.uri http://dx.doi.org/10.15488/3005
dc.identifier.uri http://www.repo.uni-hannover.de/handle/123456789/3035
dc.contributor.author Stieve, M.
dc.contributor.author Hedrich, H.J.
dc.contributor.author Battmer, R.D.
dc.contributor.author Behrens, P.
dc.contributor.author Müller, P.
dc.contributor.author Lenarz, T.
dc.date.accessioned 2018-03-01T08:47:20Z
dc.date.available 2018-03-01T08:47:20Z
dc.date.issued 2009
dc.identifier.citation Stieve, M.; Hedrich, H.J.; Battmer, R.D.; Behrens, P.; Müller, P. et al.: Experimental middle ear surgery in rabbits: A new approach for reconstructing the ossicular chain. In: Laboratory Animals 43 (2009), Nr. 2, S. 198-204. DOI: https://doi.org/10.1258/la.2008.007152
dc.description.abstract This experimental animal study aimed at evaluating a new prosthesis to replace the ossicular chain; we developed a new technique for surgical implantation into the middle ear of rabbits. The rabbit middle ear is, owing to the relative anatomical dimensions involved, an ideal environment for implantation procedures involving the ossicles, as the surgical conditions are similar to those of the human middle ear. This study included a total of 34 approximately six-month-old female white rabbits (New Zealand) weighing between 3.2 and 4.4 kg. The implants used were constructed of ceramic materials (titania, TiO2) of various pore sizes. Directly prior to implanting the total ossicular reconstruction prostheses (TORPs), as well as at 28, 84 and 300 days after implantation, electric response audiometry was used to determine the hearing thresholds of the animals (bone conduction; click stimulus nHL). An erbium:YAG laser was used to excise the original ossicular chain. Following implantation, we were unable to detect any stenosis of the outer ear canal or perforation of the tympanic membrane. The conductive hearing threshold was in the range of 4.21 ± 6.68 dB nHL (n = 131). The hearing level showed no significant difference before and after surgery (P < 0.05). eng
dc.language.iso eng
dc.publisher London : SAGE Publications Ltd.
dc.relation.ispartofseries Laboratory Animals 43 (2009), Nr. 2
dc.rights Es gilt deutsches Urheberrecht. Das Dokument darf zum eigenen Gebrauch kostenfrei genutzt, aber nicht im Internet bereitgestellt oder an Außenstehende weitergegeben werden. Dieser Beitrag ist aufgrund einer (DFG-geförderten) Allianz- bzw. Nationallizenz frei zugänglich.
dc.subject Brain response audiometry eng
dc.subject Experimental middle ear surgery eng
dc.subject Ossicular chain prostheses eng
dc.subject Rabbit eng
dc.subject article eng
dc.subject audiometry eng
dc.subject auditory ossicle eng
dc.subject auditory threshold eng
dc.subject controlled study eng
dc.subject eardrum eng
dc.subject erbium YAG laser eng
dc.subject experimental animal eng
dc.subject female eng
dc.subject implant eng
dc.subject middle ear reconstruction eng
dc.subject middle ear surgery eng
dc.subject nonhuman eng
dc.subject rabbit eng
dc.subject stenosis eng
dc.subject surgical technique eng
dc.subject Animals eng
dc.subject Audiometry, Evoked Response eng
dc.subject Ear Ossicles eng
dc.subject Female eng
dc.subject Ossicular Prosthesis eng
dc.subject Ossicular Replacement eng
dc.subject Rabbits eng
dc.subject Statistics, Nonparametric eng
dc.subject Titanium eng
dc.subject Animalia eng
dc.subject Oryctolagus cuniculus eng
dc.subject.ddc 590 | Tiere (Zoologie) ger
dc.title Experimental middle ear surgery in rabbits: A new approach for reconstructing the ossicular chain
dc.type article
dc.type Text
dc.relation.issn 0023-6772
dc.relation.doi https://doi.org/10.1258/la.2008.007152
dc.bibliographicCitation.issue 2
dc.bibliographicCitation.volume 43
dc.bibliographicCitation.firstPage 198
dc.bibliographicCitation.lastPage 204
dc.description.version publishedVersion
tib.accessRights frei zug�nglich

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