Experimental middle ear surgery in rabbits: A new approach for reconstructing the ossicular chain

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Stieve, M.; Hedrich, H.J.; Battmer, R.D.; Behrens, P.; Müller, P. et al.: Experimental middle ear surgery in rabbits: A new approach for reconstructing the ossicular chain. In: Laboratory Animals 43 (2009), Nr. 2, S. 198-204. DOI: https://doi.org/10.1258/la.2008.007152

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Sum total of downloads: 30




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This experimental animal study aimed at evaluating a new prosthesis to replace the ossicular chain; we developed a new technique for surgical implantation into the middle ear of rabbits. The rabbit middle ear is, owing to the relative anatomical dimensions involved, an ideal environment for implantation procedures involving the ossicles, as the surgical conditions are similar to those of the human middle ear. This study included a total of 34 approximately six-month-old female white rabbits (New Zealand) weighing between 3.2 and 4.4 kg. The implants used were constructed of ceramic materials (titania, TiO2) of various pore sizes. Directly prior to implanting the total ossicular reconstruction prostheses (TORPs), as well as at 28, 84 and 300 days after implantation, electric response audiometry was used to determine the hearing thresholds of the animals (bone conduction; click stimulus nHL). An erbium:YAG laser was used to excise the original ossicular chain. Following implantation, we were unable to detect any stenosis of the outer ear canal or perforation of the tympanic membrane. The conductive hearing threshold was in the range of 4.21 ± 6.68 dB nHL (n = 131). The hearing level showed no significant difference before and after surgery (P < 0.05).
License of this version: Es gilt deutsches Urheberrecht. Das Dokument darf zum eigenen Gebrauch kostenfrei genutzt, aber nicht im Internet bereitgestellt oder an Außenstehende weitergegeben werden. Dieser Beitrag ist aufgrund einer (DFG-geförderten) Allianz- bzw. Nationallizenz frei zugänglich.
Document Type: article
Publishing status: publishedVersion
Issue Date: 2009
Appears in Collections:Naturwissenschaftliche Fakultät

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pos. country downloads
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1 image of flag of Germany Germany 22 73.33%
2 image of flag of United States United States 3 10.00%
3 image of flag of Iraq Iraq 1 3.33%
4 image of flag of India India 1 3.33%
5 image of flag of Israel Israel 1 3.33%
6 image of flag of Greece Greece 1 3.33%
7 image of flag of France France 1 3.33%

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