Signal and response properties indicate an optoacoustic effect underlying the intra-cochlear laser-optical stimulation

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dc.identifier.uri Kallweit, Nicole Baumhoff, Peter Krueger, Alexander Tinne, Nadine Heisterkamp, Alexander Kral, Andrej Maier, Hannes Ripken, Tammo
dc.contributor.editor Choi, Bernard
dc.contributor.editor Kollian, Nikiforos
dc.contributor.editor Zeng, Haishan
dc.contributor.editor Kang, Hyun Wook
dc.contributor.editor Wong, Brian J.F.
dc.contributor.editor Ilgner, Justus F.
dc.contributor.editor Tearney, Guillermo J.
dc.contributor.editor Gregory, Kenton W.
dc.contributor.editor Marcu, Laura
dc.contributor.editor Skala, Melissa C.
dc.contributor.editor Campagnola, Paul J.
dc.contributor.editor Mandelis, Andreas 2017-12-12T11:54:20Z 2017-12-12T11:54:20Z 2016
dc.identifier.citation Kallweit, N.; Baumhoff, P.; Krueger, A.; Tinne, N.; Heisterkamp, A. et al.: Signal and response properties indicate an optoacoustic effect underlying the intra-cochlear laser-optical stimulation. In: Proceedings of SPIE 9689 (2016), 96892G. DOI:
dc.description.abstract Optical cochlea stimulation is under investigation as a potential alternative to conventional electric cochlea implants in treatment of sensorineural hearing loss. If direct optical stimulation of spiral ganglion neurons (SGNs) would be feasible, a smaller stimulation volume and, therefore, an improved frequency resolution could be achieved. However, it is unclear whether the mechanism of optical stimulation is based on direct neuronal stimulation or on optoacoustics. Animal studies on hearing vs. deafened guinea pigs already identified the optoacoustic effect as potential mechanism for intra-cochlear optical stimulation. In order to characterize the optoacoustic stimulus more thoroughly the acoustic signal along the beam path of a pulsed laser in water was quantified and compared to the neuronal response properties of hearing guinea pigs stimulated with the same laser parameters. Two pulsed laser systems were used for analyzing the influence of variable pulse duration, pulse energy, pulse peak power and absorption coefficient. Preliminary results of the experiments in water and in vivo suggesta similar dependency of response signals on the applied laser parameters: Both datasets show an onset and offset signal at the beginning and the end of the laser pulse. Further, the resulting signal amplitude depends on the pulse peak power as well as the temporal development of the applied laser pulse. The data indicates the maximum of the first derivative of power as the decisive factor. In conclusion our findings strengthen the hypothesis of optoacoustics as the underlying mechanism for optical stimulation of the cochlea. © SPIE 2016 eng
dc.language.iso eng
dc.publisher Bellingham, WA : S P I E - International Society for Optical Engineering
dc.relation.ispartofseries Proceedings of SPIE 9689 (2016)
dc.rights Es gilt deutsches Urheberrecht. Das Dokument darf zum eigenen Gebrauch kostenfrei genutzt, aber nicht im Internet bereitgestellt oder an Außenstehende weitergegeben werden. Dieser Beitrag ist aufgrund einer (DFG-geförderten) Allianz- bzw. Nationallizenz frei zugänglich.
dc.subject Pulsed laser operation eng
dc.subject In vivo imaging eng
dc.subject Signal detection eng
dc.subject Absorption eng
dc.subject Laser systems engineering eng
dc.subject Infrared radiation eng
dc.subject Sensors eng
dc.subject.classification Konferenzschrift ger
dc.subject.ddc 620 | Ingenieurwissenschaften und Maschinenbau ger
dc.title Signal and response properties indicate an optoacoustic effect underlying the intra-cochlear laser-optical stimulation eng
dc.type BookPart
dc.type Text
dc.relation.essn 1996-756X
dc.relation.isbn 978-1-62841-924-5
dc.relation.issn 0277-786X
dc.bibliographicCitation.volume 9689
dc.bibliographicCitation.firstPage 96892G
dc.description.version publishedVersion
tib.accessRights frei zug�nglich

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