Signal and response properties indicate an optoacoustic effect underlying the intra-cochlear laser-optical stimulation

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Kallweit, N.; Baumhoff, P.; Krueger, A.; Tinne, N.; Heisterkamp, A. et al.: Signal and response properties indicate an optoacoustic effect underlying the intra-cochlear laser-optical stimulation. In: Proceedings of SPIE 9689 (2016), 96892G. DOI: https://doi.org/10.1117/12.2210926

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Abstract: 
Optical cochlea stimulation is under investigation as a potential alternative to conventional electric cochlea implants in treatment of sensorineural hearing loss. If direct optical stimulation of spiral ganglion neurons (SGNs) would be feasible, a smaller stimulation volume and, therefore, an improved frequency resolution could be achieved. However, it is unclear whether the mechanism of optical stimulation is based on direct neuronal stimulation or on optoacoustics. Animal studies on hearing vs. deafened guinea pigs already identified the optoacoustic effect as potential mechanism for intra-cochlear optical stimulation. In order to characterize the optoacoustic stimulus more thoroughly the acoustic signal along the beam path of a pulsed laser in water was quantified and compared to the neuronal response properties of hearing guinea pigs stimulated with the same laser parameters. Two pulsed laser systems were used for analyzing the influence of variable pulse duration, pulse energy, pulse peak power and absorption coefficient. Preliminary results of the experiments in water and in vivo suggesta similar dependency of response signals on the applied laser parameters: Both datasets show an onset and offset signal at the beginning and the end of the laser pulse. Further, the resulting signal amplitude depends on the pulse peak power as well as the temporal development of the applied laser pulse. The data indicates the maximum of the first derivative of power as the decisive factor. In conclusion our findings strengthen the hypothesis of optoacoustics as the underlying mechanism for optical stimulation of the cochlea. © SPIE 2016
License of this version: Es gilt deutsches Urheberrecht. Das Dokument darf zum eigenen Gebrauch kostenfrei genutzt, aber nicht im Internet bereitgestellt oder an Außenstehende weitergegeben werden. Dieser Beitrag ist aufgrund einer (DFG-geförderten) Allianz- bzw. Nationallizenz frei zugänglich.
Document Type: article
Publishing status: publishedVersion
Issue Date: 2016
Appears in Collections:Fakultät für Mathematik und Physik

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1 image of flag of Germany Germany 198 90.83%
2 image of flag of United States United States 12 5.50%
3 image of flag of Japan Japan 2 0.92%
4 image of flag of Norway Norway 1 0.46%
5 image of flag of Iran, Islamic Republic of Iran, Islamic Republic of 1 0.46%
6 image of flag of Hong Kong Hong Kong 1 0.46%
7 image of flag of China China 1 0.46%
8 image of flag of Switzerland Switzerland 1 0.46%
9 image of flag of Belgium Belgium 1 0.46%

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