Low-cost, in-liquid measuring system using a novel compact oscillation circuit and quartz-crystal microbalances (QCMs) as a versatile biosensor platform

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dc.identifier.uri http://dx.doi.org/10.15488/2276
dc.identifier.uri http://www.repo.uni-hannover.de/handle/123456789/2302
dc.contributor.author Beißner, S.
dc.contributor.author Thies, J.-W.
dc.contributor.author Bechthold, C.
dc.contributor.author Kuhn, P.
dc.contributor.author Thürmann, B.
dc.contributor.author Dübel, S.
dc.contributor.author Dietzel, A.
dc.date.accessioned 2017-11-13T08:18:13Z
dc.date.available 2017-11-13T08:18:13Z
dc.date.issued 2017
dc.identifier.citation Beißner, S.; Thies, J.-W.; Bechthold, C.; Kuhn, P.; Thürmann, B. et al.: Low-cost, in-liquid measuring system using a novel compact oscillation circuit and quartz-crystal microbalances (QCMs) as a versatile biosensor platform. In: Journal of Sensors and Sensor Systems 6 (2017), Nr. 2, S. 341-350. DOI: https://doi.org/10.5194/jsss-6-341-2017
dc.description.abstract Quartz-crystal microbalances (QCMs) are commercially available mass sensors which mainly consist of a quartz resonator that oscillates at a characteristic frequency, which shifts when mass changes due to surface binding of molecules. In addition to mass changes, the viscosity of gases or liquids in contact with the sensor also shifts the resonance but also influences the quality factor (Q-factor). Typical biosensor applications demand operation in liquid environments leading to viscous damping strongly lowering Q-factors. For obtaining reliable measurements in liquid environments, excellent resonator control and signal processing are essential but standard resonator circuits like the Pierce and Colpitts oscillator fail to establish stable resonances. Here we present a low-cost, compact and robust oscillator circuit comprising of state-of-the-art commercially available surface-mount technology components which stimulates the QCMs oscillation, while it also establishes a control loop regulating the applied voltage. Thereby an increased energy dissipation by strong viscous damping in liquid solutions can be compensated and oscillations are stabilized. The presented circuit is suitable to be used in compact biosensor systems using custom-made miniaturized QCMs in microfluidic environments. As a proof of concept we used this circuit in combination with a customized microfabricated QCM in a microfluidic environment to measure the concentration of C-reactive protein (CRP) in buffer (PBS) down to concentrations as low as 5 μg mL-1. © 2017 Author(s). eng
dc.language.iso eng
dc.publisher Göttingen : Copernicus GmbH
dc.relation.ispartofseries Journal of Sensors and Sensor Systems 6 (2017), Nr. 2
dc.rights CC BY 3.0 Unported
dc.rights.uri https://creativecommons.org/licenses/by/3.0/
dc.subject Quartz-crystal microbalances eng
dc.subject QCM eng
dc.subject C-reactive protein (CRP) eng
dc.subject sensor eng
dc.subject.ddc 600 | Technik ger
dc.title Low-cost, in-liquid measuring system using a novel compact oscillation circuit and quartz-crystal microbalances (QCMs) as a versatile biosensor platform
dc.type article
dc.type Text
dc.relation.issn 2194-8771
dc.relation.doi https://doi.org/10.5194/jsss-6-341-2017
dc.bibliographicCitation.issue 2
dc.bibliographicCitation.volume 6
dc.bibliographicCitation.firstPage 341
dc.bibliographicCitation.lastPage 350
dc.description.version publishedVersion
tib.accessRights frei zug�nglich


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