dc.identifier.uri |
http://dx.doi.org/10.15488/2155 |
|
dc.identifier.uri |
http://www.repo.uni-hannover.de/handle/123456789/2180 |
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dc.contributor.author |
Paleek, Jiri
|
|
dc.contributor.author |
Zweigerdt, Robert
|
|
dc.contributor.author |
Olmer, Ruth
|
|
dc.contributor.author |
Martin, Ulrich
|
|
dc.contributor.author |
Kirschning, Andreas
|
|
dc.contributor.author |
Dräger, Gerald
|
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dc.date.accessioned |
2017-10-30T13:12:53Z |
|
dc.date.available |
2017-10-30T13:12:53Z |
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dc.date.issued |
2011 |
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dc.identifier.citation |
Paleek, J.; Zweigerdt, R.; Olmer, R.; Martin, U.; Kirschning, A. et al.: A practical synthesis of Rho-Kinase inhibitor Y-27632 and fluoro derivatives and their evaluation in human pluripotent stem cells. In: Organic and Biomolecular Chemistry 9 (2011), Nr. 15, S. 5503-5510. DOI: https://doi.org/10.1039/c1ob05332a |
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dc.description.abstract |
A practical synthesis of the Rho-Kinase inhibitor Y-27632 and two new fluoro derivatives was achieved in seven steps and with a good overall yield of 45% starting from commercially available (R)-1-phenylethylamine. Compared to Y-27632 the new fluoro derivatives showed reduced or no effect on hPSC vitality and expansion after dissociation in human pluripotent stem cells. © 2011 The Royal Society of Chemistry. |
eng |
dc.language.iso |
eng |
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dc.publisher |
Cambridge : Royal Society of Chemistry |
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dc.relation.ispartofseries |
Organic and Biomolecular Chemistry 9 (2011), Nr. 15 |
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dc.rights |
Es gilt deutsches Urheberrecht. Das Dokument darf zum eigenen Gebrauch kostenfrei genutzt, aber nicht im Internet bereitgestellt oder an Außenstehende weitergegeben werden. Dieser Beitrag ist aufgrund einer (DFG-geförderten) Allianz- bzw. Nationallizenz frei zugänglich. |
|
dc.subject |
Phenylethylamines |
eng |
dc.subject |
Pluripotent stem cells |
eng |
dc.subject |
Rho-kinase inhibitors |
eng |
dc.subject |
Enzymes |
eng |
dc.subject |
Stem cells |
eng |
dc.subject |
4 (1 aminoethyl) n (4 pyridyl)cyclohexanecarboxamide |
eng |
dc.subject |
amide |
eng |
dc.subject |
enzyme inhibitor |
eng |
dc.subject |
fluorine |
eng |
dc.subject |
pyridine derivative |
eng |
dc.subject |
Rho kinase |
eng |
dc.subject |
article |
eng |
dc.subject |
cell culture |
eng |
dc.subject |
cell proliferation |
eng |
dc.subject |
chemical structure |
eng |
dc.subject |
chemistry |
eng |
dc.subject |
drug antagonism |
eng |
dc.subject |
drug effect |
eng |
dc.subject |
human |
eng |
dc.subject |
nuclear magnetic resonance spectroscopy |
eng |
dc.subject |
pluripotent stem cell |
eng |
dc.subject |
synthesis |
eng |
dc.subject |
Amides |
eng |
dc.subject |
Cell Proliferation |
eng |
dc.subject |
Cells, Cultured |
eng |
dc.subject |
Enzyme Inhibitors |
eng |
dc.subject |
Fluorine |
eng |
dc.subject |
Humans |
eng |
dc.subject |
Magnetic Resonance Spectroscopy |
eng |
dc.subject |
Molecular Structure |
eng |
dc.subject |
Pluripotent Stem Cells |
eng |
dc.subject |
Pyridines |
eng |
dc.subject |
rho-Associated Kinases |
eng |
dc.subject.ddc |
540 | Chemie
|
ger |
dc.title |
A practical synthesis of Rho-Kinase inhibitor Y-27632 and fluoro derivatives and their evaluation in human pluripotent stem cells |
eng |
dc.type |
Article |
|
dc.type |
Text |
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dc.relation.issn |
1477-0520 |
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dc.relation.doi |
https://doi.org/10.1039/c1ob05332a |
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dc.bibliographicCitation.issue |
15 |
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dc.bibliographicCitation.volume |
9 |
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dc.bibliographicCitation.firstPage |
5503 |
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dc.bibliographicCitation.lastPage |
5510 |
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dc.description.version |
publishedVersion |
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tib.accessRights |
frei zug�nglich |
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