dc.identifier.uri |
http://dx.doi.org/10.15488/1799 |
|
dc.identifier.uri |
http://www.repo.uni-hannover.de/handle/123456789/1824 |
|
dc.contributor.author |
Chen, Wanping
|
|
dc.contributor.author |
Chen, Runfa
|
|
dc.contributor.author |
Liu, Qingpei
|
|
dc.contributor.author |
He, Yi
|
|
dc.contributor.author |
He, Kun
|
|
dc.contributor.author |
Ding, Xiaoli
|
|
dc.contributor.author |
Kang, Lijing
|
|
dc.contributor.author |
Guo, Xiaoxiao
|
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dc.contributor.author |
Xie, Nana
|
|
dc.contributor.author |
Zhou, Youxiang
|
|
dc.contributor.author |
Lu, Yuanyuan
|
|
dc.contributor.author |
Cox, Russell J.
|
|
dc.contributor.author |
Molnár, Istvan
|
|
dc.contributor.author |
Li, Mu
|
|
dc.contributor.author |
Shao, Yanchun
|
|
dc.contributor.author |
Chen, Fusheng
|
|
dc.date.accessioned |
2017-08-30T11:46:22Z |
|
dc.date.available |
2017-08-30T11:46:22Z |
|
dc.date.issued |
2017 |
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dc.identifier.citation |
Chen, W.; Chen, R.; Liu, Q.; He, Y.; He, K. et al.: Orange, red, yellow: Biosynthesis of azaphilone pigments in Monascus fungi. In: Chemical Science 8 (2017), Nr. 7, S. 4917-4925. DOI: https://doi.org/10.1039/c7sc00475c |
|
dc.description.abstract |
Monascus azaphilone pigments (MonAzPs) are very widely used as food colorants, but their biosynthetic pathway has remained poorly characterized for more than half a century. In this study, the individual steps of MonAzPs biosynthesis in Monascus ruber M7 were elucidated by a combination of targeted gene knockouts, heterologous gene expression, and in vitro chemical and enzymatic reactions. This study describes the first rational engineering of MonAzPs biosynthesis and provides a roadmap for future pathway engineering efforts directed towards the selective production of the most valuable pigments and serves as a model for the biosynthesis of fungal azaphilones in general. |
eng |
dc.description.sponsorship |
National Natural Science Foundation of China |
|
dc.description.sponsorship |
National Institutes of Health |
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dc.description.sponsorship |
DFG/INST 187/621-1 |
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dc.language.iso |
eng |
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dc.publisher |
Cambridge : Royal Society of Chemistry |
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dc.relation.ispartofseries |
Chemical Science 8 (2017), Nr. 7 |
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dc.rights |
CC BY-NC 3.0 Unported |
|
dc.rights.uri |
https://creativecommons.org/licenses/by-nc/3.0/ |
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dc.subject |
Biochemistry |
eng |
dc.subject |
Gene expression |
eng |
dc.subject |
Genes |
eng |
dc.subject |
Biosynthetic pathway |
eng |
dc.subject |
Enzymatic reaction |
eng |
dc.subject |
Food colorants |
eng |
dc.subject |
Gene knockout |
eng |
dc.subject |
Heterologous gene expressions |
eng |
dc.subject |
In-vitro |
eng |
dc.subject |
Pathway engineerings |
eng |
dc.subject |
Selective production |
eng |
dc.subject |
Biosynthesis |
eng |
dc.subject.ddc |
540 | Chemie
|
ger |
dc.title |
Orange, red, yellow: Biosynthesis of azaphilone pigments in Monascus fungi |
|
dc.type |
Article |
|
dc.type |
Text |
|
dc.relation.essn |
2041-6539 |
|
dc.relation.issn |
2041-6520 |
|
dc.relation.doi |
https://doi.org/10.1039/c7sc00475c |
|
dc.bibliographicCitation.issue |
7 |
|
dc.bibliographicCitation.volume |
8 |
|
dc.bibliographicCitation.firstPage |
4917 |
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dc.bibliographicCitation.lastPage |
4925 |
|
dc.description.version |
publishedVersion |
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tib.accessRights |
frei zug�nglich |
|