Orange, red, yellow: Biosynthesis of azaphilone pigments in Monascus fungi

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dc.identifier.uri Chen, Wanping Chen, Runfa Liu, Qingpei He, Yi He, Kun Ding, Xiaoli Kang, Lijing Guo, Xiaoxiao Xie, Nana Zhou, Youxiang Lu, Yuanyuan Cox, Russell J. Molnár, Istvan Li, Mu Shao, Yanchun Chen, Fusheng 2017-08-30T11:46:22Z 2017-08-30T11:46:22Z 2017
dc.identifier.citation Chen, W.; Chen, R.; Liu, Q.; He, Y.; He, K. et al.: Orange, red, yellow: Biosynthesis of azaphilone pigments in Monascus fungi. In: Chemical Science 8 (2017), Nr. 7, S. 4917-4925. DOI:
dc.description.abstract Monascus azaphilone pigments (MonAzPs) are very widely used as food colorants, but their biosynthetic pathway has remained poorly characterized for more than half a century. In this study, the individual steps of MonAzPs biosynthesis in Monascus ruber M7 were elucidated by a combination of targeted gene knockouts, heterologous gene expression, and in vitro chemical and enzymatic reactions. This study describes the first rational engineering of MonAzPs biosynthesis and provides a roadmap for future pathway engineering efforts directed towards the selective production of the most valuable pigments and serves as a model for the biosynthesis of fungal azaphilones in general. eng
dc.description.sponsorship National Natural Science Foundation of China
dc.description.sponsorship National Institutes of Health
dc.description.sponsorship DFG/INST 187/621-1
dc.language.iso eng
dc.publisher Cambridge : Royal Society of Chemistry
dc.relation.ispartofseries Chemical Science 8 (2017), Nr. 7
dc.rights CC BY-NC 3.0 Unported
dc.subject Biochemistry eng
dc.subject Gene expression eng
dc.subject Genes eng
dc.subject Biosynthetic pathway eng
dc.subject Enzymatic reaction eng
dc.subject Food colorants eng
dc.subject Gene knockout eng
dc.subject Heterologous gene expressions eng
dc.subject In-vitro eng
dc.subject Pathway engineerings eng
dc.subject Selective production eng
dc.subject Biosynthesis eng
dc.subject.ddc 540 | Chemie ger
dc.title Orange, red, yellow: Biosynthesis of azaphilone pigments in Monascus fungi
dc.type Article
dc.type Text
dc.relation.essn 2041-6539
dc.relation.issn 2041-6520
dc.bibliographicCitation.issue 7
dc.bibliographicCitation.volume 8
dc.bibliographicCitation.firstPage 4917
dc.bibliographicCitation.lastPage 4925
dc.description.version publishedVersion
tib.accessRights frei zug�nglich

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