Cytotoxicity of titanium and silicon dioxide nanoparticles

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dc.identifier.uri Wagner, Stefanie Münzer, Simon Behrens, Peter Scheper, Thomas Bahnemann, Detlef W. Kasper, Cornelia 2017-05-10T11:33:52Z 2017-05-10T11:33:52Z 2009
dc.identifier.citation Wagner, S.; Münzer, S.; Behrens, P.; Scheper, T.; Bahnemann, D. et al.: Cytotoxicity of titanium and silicon dioxide nanoparticles. In: Journal of Physics: Conference Series 170 (2009), 12022. DOI:
dc.description.abstract Different TiO 2 and SiO 2 nanoparticles have been tested concerning their toxicity on selected mammalian cell lines. Various powders and suspensions, all of which consist of titanium or silicon dioxide nanoparticles have been examined. These particles differ in the crystal structure, the size and the BET-surface area. There was also a classification in fixed particles and in particles easily accessible in solution. With focus on the possible adsorption of the nanoparticles into the human organism, via skin and via respiratory tract, the effects on fibroblasts (NIH-3T3) and on a human lung adenocarcinoma epithelial cell line were examined. Additionally, the particles were tested with HEP-G2 cells, which are often used as model cell line for biocompatibility tests, and PC-12 cells, a rat adrenal pheochromocytoma cell line. The viability of the cells was examined by the MTT-test. The viability results were found to partly depend on the type of cells used. The experimental results show that the adhesion of the cells on the different powders strongly depends on the type of cell lines as well as on the type of powder. It was found that the lower viability of some cells on the powder coatings is not only caused by a cytotoxicity effect of the powders, but is also due to a lower adhesion of the cells on the particle surfaces. Furthermore, it could be shown that the physical properties of the powders cannot be easily correlated to any observed biological effect. While some powders show a significant suppression of the cell growth, others with similar physical properties indicate no toxic effect. eng
dc.language.iso eng
dc.publisher Bristol : IOP Publishing Ltd.
dc.relation.ispartofseries Journal of Physics: Conference Series 170 (2009)
dc.rights CC BY 3.0 Unported
dc.subject TiO 2 eng
dc.subject SiO 2 eng
dc.subject nanoparticles eng
dc.subject Cytotoxicity eng
dc.subject.classification Konferenzschrift ger
dc.subject.ddc 530 | Physik ger
dc.title Cytotoxicity of titanium and silicon dioxide nanoparticles eng
dc.type article
dc.type Text
dc.relation.issn 1742-6588
dc.bibliographicCitation.volume 170
dc.bibliographicCitation.firstPage 12022
dc.description.version publishedVersion
tib.accessRights frei zug�nglich

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