Cytotoxicity of titanium and silicon dioxide nanoparticles

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Wagner, S.; Münzer, S.; Behrens, P.; Scheper, T.; Bahnemann, D. et al.: Cytotoxicity of titanium and silicon dioxide nanoparticles. In: Journal of Physics: Conference Series 170 (2009), 12022. DOI:

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Sum total of downloads: 178

Different TiO 2 and SiO 2 nanoparticles have been tested concerning their toxicity on selected mammalian cell lines. Various powders and suspensions, all of which consist of titanium or silicon dioxide nanoparticles have been examined. These particles differ in the crystal structure, the size and the BET-surface area. There was also a classification in fixed particles and in particles easily accessible in solution. With focus on the possible adsorption of the nanoparticles into the human organism, via skin and via respiratory tract, the effects on fibroblasts (NIH-3T3) and on a human lung adenocarcinoma epithelial cell line were examined. Additionally, the particles were tested with HEP-G2 cells, which are often used as model cell line for biocompatibility tests, and PC-12 cells, a rat adrenal pheochromocytoma cell line. The viability of the cells was examined by the MTT-test. The viability results were found to partly depend on the type of cells used. The experimental results show that the adhesion of the cells on the different powders strongly depends on the type of cell lines as well as on the type of powder. It was found that the lower viability of some cells on the powder coatings is not only caused by a cytotoxicity effect of the powders, but is also due to a lower adhesion of the cells on the particle surfaces. Furthermore, it could be shown that the physical properties of the powders cannot be easily correlated to any observed biological effect. While some powders show a significant suppression of the cell growth, others with similar physical properties indicate no toxic effect.
License of this version: CC BY 3.0 Unported
Document Type: article
Publishing status: publishedVersion
Issue Date: 2009
Appears in Collections:Naturwissenschaftliche Fakultät

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pos. country downloads
total perc.
1 image of flag of Germany Germany 133 74.72%
2 image of flag of United States United States 10 5.62%
3 image of flag of Ukraine Ukraine 4 2.25%
4 image of flag of India India 4 2.25%
5 image of flag of Russian Federation Russian Federation 3 1.69%
6 image of flag of China China 3 1.69%
7 image of flag of Korea, Republic of Korea, Republic of 2 1.12%
8 image of flag of United Kingdom United Kingdom 2 1.12%
9 image of flag of France France 2 1.12%
10 image of flag of Brazil Brazil 2 1.12%
    other countries 13 7.30%

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