Dudkina, N.V.; Sunderhaus, S.; Boekema, E.J.; Braun, H.-P.: The higher level of organization of the oxidative phosphorylation system: Mitochondrial supercomplexes. In: Journal of bioenergetics and biomembranes 40 (2008), S. 419-424. DOI:
https://doi.org/10.1007/s10863-008-9167-5
Zusammenfassung: |
The organization of the oxidative phosphorylation (OXPHOS) system within the inner mitochondrial membrane appears to be far more complicated than previously thought. In particular, the individual protein complexes of the OXPHOS system (complexes I to V) were found to specifically interact forming defined supramolecular structures. Blue-native polyacrylamide gel electrophoresis and single particle electron microscopy proved to be especially valuable in studying the so-called "respiratory supercomplexes". Based on these procedures, increasing evidence was presented supporting a "solid state" organization of the OXPHOS system. Here, we summarize results on the formation, organisation and function of the various types of mitochondrial OXPHOS supercomplexes.
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Lizenzbestimmungen: |
CC BY-NC 2.0 Unported - https://creativecommons.org/licenses/by-nc/2.0/
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Publikationstyp: |
Article |
Publikationsstatus: |
publishedVersion |
Erstveröffentlichung: |
2008 |
Schlagwörter (englisch): |
Electron microscopy, Mitochondria, Oxidative phosphorylation, Respirasome, Supercomplexes, cytochrome c, cytochrome c oxidase, proton transporting adenosine triphosphate synthase, reduced nicotinamide adenine dinucleotide dehydrogenase (ubiquinone), succinate dehydrogenase (ubiquinone), ubiquinol cytochrome c reductase, complex formation, enzyme activity, enzyme synthesis, enzymology, mitochondrial membrane, mitochondrial respiration, nonhuman, oxidative phosphorylation, respiratory chain, review, Animals, Electron Transport Chain Complex Proteins, Electrophoresis, Polyacrylamide Gel, Microscopy, Electron, Mitochondria, Mitochondrial Proton-Translocating ATPases, Models, Biological, Models, Molecular, Oxidative Phosphorylation, Protein Structure, Quaternary
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Fachliche Zuordnung (DDC): |
570 | Biowissenschaften, Biologie
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