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dc.identifier.uri Berthoud, Viviana M. Ngezahayo, Anaclet 2017-02-07T11:12:10Z 2017-02-07T11:12:10Z 2017
dc.identifier.citation Berthoud, Viviana M.; Ngezahayo, Anaclet: Focus on lens connexins. In: BMC Cell Biology 18 (2017), Suppl. 1, 6. DOI:
dc.description.abstract The lens is an avascular organ composed of an anterior epithelial cell layer and fiber cells that form the bulk of the organ. The lens expresses connexin43 (Cx43), connexin46 (Cx46) and connexin50 (Cx50). Epithelial Cx50 has critical roles in cell proliferation and differentiation, likely involving growth factor-dependent signaling pathways. Both Cx46 and Cx50 are crucial for lens transparency; mutations in their genes have been linked to congenital and age-related cataracts. Congenital cataract-associated connexin mutants can affect protein trafficking, stability and/or function, and the functional effects may differ between gap junction channels and hemichannels. Dominantly inherited cataracts may result from effects of the connexin mutant on its wild type isotype, the other co-expressed wild type connexin and/or its interaction with other cellular components. eng
dc.description.sponsorship NIH/RO1EY08368
dc.description.sponsorship DFG/SFB/Transregio37
dc.description.sponsorship US National Institutes of Health/RO1EY08368
dc.description.sponsorship DFG/SFB/Transregio 37
dc.language.iso eng
dc.publisher London : Biomed Central
dc.relation.ispartofseries BMC Cell Biology 18 (2017), Suppl. 1
dc.rights CC BY 4.0 Unported
dc.subject ocular lens eng
dc.subject Ubiquitylation eng
dc.subject Phosphorylation eng
dc.subject Lens connexin function eng
dc.subject Congenital cataracts eng
dc.subject.ddc 500 | Naturwissenschaften ger
dc.subject.ddc 570 | Biowissenschaften, Biologie ger
dc.title Focus on lens connexins
dc.type article
dc.type Text
dc.relation.essn 1471-2121
dc.bibliographicCitation.issue Suppl. 1
dc.bibliographicCitation.volume 18
dc.bibliographicCitation.firstPage 6
dc.description.version publishedVersion
tib.accessRights frei zug�nglich

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