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Berthoud, Viviana M.; Ngezahayo, Anaclet: Focus on lens connexins. In: BMC Cell Biology 18 (2017), Suppl. 1, 6. DOI: https://doi.org/10.1186/s12860-016-0116-6

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Sum total of downloads: 154




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Abstract: 
The lens is an avascular organ composed of an anterior epithelial cell layer and fiber cells that form the bulk of the organ. The lens expresses connexin43 (Cx43), connexin46 (Cx46) and connexin50 (Cx50). Epithelial Cx50 has critical roles in cell proliferation and differentiation, likely involving growth factor-dependent signaling pathways. Both Cx46 and Cx50 are crucial for lens transparency; mutations in their genes have been linked to congenital and age-related cataracts. Congenital cataract-associated connexin mutants can affect protein trafficking, stability and/or function, and the functional effects may differ between gap junction channels and hemichannels. Dominantly inherited cataracts may result from effects of the connexin mutant on its wild type isotype, the other co-expressed wild type connexin and/or its interaction with other cellular components.
License of this version: CC BY 4.0 Unported
Document Type: article
Publishing status: publishedVersion
Issue Date: 2017
Appears in Collections:Naturwissenschaftliche Fakultät

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pos. country downloads
total perc.
1 image of flag of Germany Germany 143 92.86%
2 image of flag of United States United States 3 1.95%
3 image of flag of Switzerland Switzerland 2 1.30%
4 image of flag of Romania Romania 1 0.65%
5 image of flag of Poland Poland 1 0.65%
6 image of flag of Korea, Republic of Korea, Republic of 1 0.65%
7 image of flag of India India 1 0.65%
8 image of flag of Indonesia Indonesia 1 0.65%
9 image of flag of Guatemala Guatemala 1 0.65%

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