Investigating the biosynthesis of Sch-642305 in the fungus : Phomopsis sp. CMU-LMA
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Original version
Trenti, F.; Lebe, K.E.; Adelin, E.; Ouazzani, J.; Schotte, C.; Cox, R.J.: Investigating the biosynthesis of Sch-642305 in the fungus : Phomopsis sp. CMU-LMA. In: RSC Advances 10 (2020), Nr. 46, S. 27369-27376. DOI:
https://doi.org/10.1039/d0ra05311b
Repository version
To cite the version in the repository, please use this identifier:
https://doi.org/10.15488/10744
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Abstract:
Sch-642305 is an unusual bicyclic 10-membered macrolide produced by the filamentous fungus Phomopsis sp. CMU-LMA for which no biosynthetic evidence exists. Here, we generate a draft genome sequence of the producing organism and discover the biosynthetic gene cluster responsible for formation of Sch-642305. Targeted gene disruptions together with reconstitution of the pathway in the heterologous host Aspergillus oryzae dissect key chemical steps and shed light on a series of oxidoreductions occuring in the pathway. © The Royal Society of Chemistry.
License of this version:
CC BY-NC 3.0 Unported -
https://creativecommons.org/licenses/by-nc/3.0/
Publication type:
Article
Publishing status:
publishedVersion
Publication date:
2020
Keywords english:
Aspergillus
,
Biochemistry
,
Genes
,
Aspergillus Oryzae
,
Biosynthetic gene cluster
,
Filamentous fungi
,
Gene disruptions
,
Genome sequences
,
Macrolides
,
Phomopsis sp
,
Biosynthesis
DDC:
540 | Chemie
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