Aptasensors for Point-of-Care Detection of Small Molecules

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dc.identifier.uri http://dx.doi.org/10.15488/10627
dc.identifier.uri https://www.repo.uni-hannover.de/handle/123456789/10705
dc.contributor.author Prante, Marc
dc.contributor.author Segal, Ester
dc.contributor.author Scheper, Thomas
dc.contributor.author Bahnemann, Janina
dc.contributor.author Walter, Johanna
dc.date.accessioned 2021-03-26T08:44:47Z
dc.date.available 2021-03-26T08:44:47Z
dc.date.issued 2020
dc.identifier.citation Prante, M.; Segal, E.; Scheper, T.; Bahnemann, J.; Walter, J.: Aptasensors for Point-of-Care Detection of Small Molecules. In: Biosensors 10 (2020), Nr. 9, 108. DOI: https://doi.org/10.3390/bios10090108
dc.description.abstract Aptamers, a group of nucleic acids which can specifically bind to a target molecule, have drawn extensive interest over the past few decades. For analytics, aptamers represent a viable alternative to gold-standard antibodies due to their oligonucleic nature combined with advantageous properties, including higher stability in harsh environments and longer shelf-life. Indeed, over the last decade, aptamers have been used in numerous bioanalytical assays and in various point-of-care testing (POCT) platforms. The latter allows for rapid on-site testing and can be performed outside a laboratory by unskilled labor. Aptamer technology for POCT is not limited just to medical diagnostics; it can be used for a range of applications, including environmental monitoring and quality control. In this review, we critically examine the use of aptamers in POCT with an emphasis on their advantages and limitations. We also examine the recent success of aptasensor technology and how these findings pave the way for the analysis of small molecules in POCT and other health-related applications. Finally, the current major limitations of aptamers are discussed, and possible approaches for overcoming these challenges are presented. © 2020 by the authors. eng
dc.language.iso eng
dc.publisher Basel : Molecular Diversity Preservation International (MDPI)
dc.relation.ispartofseries Biosensors 10 (2020), Nr. 9
dc.rights CC BY 4.0 Unported
dc.rights.uri https://creativecommons.org/licenses/by/4.0/
dc.subject aptamer eng
dc.subject healthcare eng
dc.subject POCT eng
dc.subject point-of-care testing eng
dc.subject small molecules eng
dc.subject.ddc 570 | Biowissenschaften, Biologie ger
dc.title Aptasensors for Point-of-Care Detection of Small Molecules
dc.type article
dc.type Text
dc.relation.essn 2079-6374
dc.relation.doi https://doi.org/10.3390/bios10090108
dc.bibliographicCitation.issue 9
dc.bibliographicCitation.volume 10
dc.bibliographicCitation.firstPage 108
dc.description.version publishedVersion
tib.accessRights frei zug�nglich

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