Aptasensors for Point-of-Care Detection of Small Molecules

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Prante, M.; Segal, E.; Scheper, T.; Bahnemann, J.; Walter, J.: Aptasensors for Point-of-Care Detection of Small Molecules. In: Biosensors 10 (2020), Nr. 9, 108. DOI: https://doi.org/10.3390/bios10090108

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Sum total of downloads: 63

Aptamers, a group of nucleic acids which can specifically bind to a target molecule, have drawn extensive interest over the past few decades. For analytics, aptamers represent a viable alternative to gold-standard antibodies due to their oligonucleic nature combined with advantageous properties, including higher stability in harsh environments and longer shelf-life. Indeed, over the last decade, aptamers have been used in numerous bioanalytical assays and in various point-of-care testing (POCT) platforms. The latter allows for rapid on-site testing and can be performed outside a laboratory by unskilled labor. Aptamer technology for POCT is not limited just to medical diagnostics; it can be used for a range of applications, including environmental monitoring and quality control. In this review, we critically examine the use of aptamers in POCT with an emphasis on their advantages and limitations. We also examine the recent success of aptasensor technology and how these findings pave the way for the analysis of small molecules in POCT and other health-related applications. Finally, the current major limitations of aptamers are discussed, and possible approaches for overcoming these challenges are presented. © 2020 by the authors.
License of this version: CC BY 4.0 Unported
Document Type: article
Publishing status: publishedVersion
Issue Date: 2020
Appears in Collections:Naturwissenschaftliche Fakultät

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pos. country downloads
total perc.
1 image of flag of Germany Germany 47 74.60%
2 image of flag of United States United States 8 12.70%
3 image of flag of China China 4 6.35%
4 image of flag of Vietnam Vietnam 1 1.59%
5 image of flag of No geo information available No geo information available 1 1.59%
6 image of flag of Sweden Sweden 1 1.59%
7 image of flag of Iran, Islamic Republic of Iran, Islamic Republic of 1 1.59%

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