Polypeptide self-assembled nanoparticles as delivery systems for polymyxins B and E

Show simple item record

dc.identifier.uri http://dx.doi.org/10.15488/10589
dc.identifier.uri https://www.repo.uni-hannover.de/handle/123456789/10666
dc.contributor.author Iudin, Dmitrii
dc.contributor.author Zashikhina, Natalia
dc.contributor.author Demyanova, Elena
dc.contributor.author Korzhikov-Vlakh, Viktor
dc.contributor.author Shcherbakova, Elena
dc.contributor.author Boroznjak, Roman
dc.contributor.author Tarasenko, Irina
dc.contributor.author Zakharova, Natalya
dc.contributor.author Lavrentieva, Antonina
dc.contributor.author Skorik, Yury
dc.contributor.author Korzhikova-Vlakh, Evgenia
dc.date.accessioned 2021-03-23T09:46:13Z
dc.date.available 2021-03-23T09:46:13Z
dc.date.issued 2020
dc.identifier.citation Iudin, D.; Zashikhina, N.; Demyanova, E.; Korzhikov-Vlakh, V.; Shcherbakova, E. et al.: Polypeptide self-assembled nanoparticles as delivery systems for polymyxins B and E. In: Pharmaceutics 12 (2020), Nr. 9, 868. DOI: https://doi.org/10.3390/pharmaceutics12090868
dc.description.abstract Polymyxins are peptide antibiotics that are highly efficient against many multidrug resistant pathogens. However, the poor stability of polymyxins in the bloodstream requires the administration of high drug doses that, in turn, can lead to polymyxin toxicity. Consequently, different delivery systems have been considered for polymyxins to overcome these obstacles. In this work, we report the development of polymyxin delivery systems based on nanoparticles obtained from the self-assembly of amphiphilic random poly(L-glutamic acid-co-D-phenylalanine). These P(Glu-co-DPhe) nanoparticles were characterized in terms of their size, surface charge, stability, cytotoxicity, and uptake by macrophages. The encapsulation efficiency and drug loading into P(Glu-co-DPhe) nanoparticles were determined for both polymyxin B and E. The release kinetics of polymyxins B and E from nanoformulations was studied and compared in buffer solution and human blood plasma. The release mechanisms were analyzed using a number of mathematical models. The minimal inhibitory concentrations of the nanoformulations were established and compared with those determined for the free antibiotics. © 2020 by the authors. Licensee MDPI, Basel, Switzerland. eng
dc.language.iso eng
dc.publisher Basel : MDPI AG
dc.relation.ispartofseries Pharmaceutics 12 (2020), Nr. 9
dc.rights CC BY 4.0 Unported
dc.rights.uri https://creativecommons.org/licenses/by/4.0/
dc.subject Drug delivery systems eng
dc.subject Minimal inhibitory concentration eng
dc.subject Peptide antibiotics eng
dc.subject Polymyxin loading and release eng
dc.subject Polymyxins eng
dc.subject Polypeptide nanoparticles eng
dc.subject.ddc 610 | Medizin, Gesundheit ger
dc.title Polypeptide self-assembled nanoparticles as delivery systems for polymyxins B and E
dc.type Article
dc.type Text
dc.relation.essn 1999-4923
dc.relation.doi https://doi.org/10.3390/pharmaceutics12090868
dc.bibliographicCitation.issue 9
dc.bibliographicCitation.volume 12
dc.bibliographicCitation.firstPage 868
dc.description.version publishedVersion
tib.accessRights frei zug�nglich

Files in this item

This item appears in the following Collection(s):

Show simple item record


Search the repository


My Account

Usage Statistics