Polypeptide self-assembled nanoparticles as delivery systems for polymyxins B and E

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Iudin, D.; Zashikhina, N.; Demyanova, E.; Korzhikov-Vlakh, V.; Shcherbakova, E. et al.: Polypeptide self-assembled nanoparticles as delivery systems for polymyxins B and E. In: Pharmaceutics 12 (2020), Nr. 9, 868. DOI: https://doi.org/10.3390/pharmaceutics12090868

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Polymyxins are peptide antibiotics that are highly efficient against many multidrug resistant pathogens. However, the poor stability of polymyxins in the bloodstream requires the administration of high drug doses that, in turn, can lead to polymyxin toxicity. Consequently, different delivery systems have been considered for polymyxins to overcome these obstacles. In this work, we report the development of polymyxin delivery systems based on nanoparticles obtained from the self-assembly of amphiphilic random poly(L-glutamic acid-co-D-phenylalanine). These P(Glu-co-DPhe) nanoparticles were characterized in terms of their size, surface charge, stability, cytotoxicity, and uptake by macrophages. The encapsulation efficiency and drug loading into P(Glu-co-DPhe) nanoparticles were determined for both polymyxin B and E. The release kinetics of polymyxins B and E from nanoformulations was studied and compared in buffer solution and human blood plasma. The release mechanisms were analyzed using a number of mathematical models. The minimal inhibitory concentrations of the nanoformulations were established and compared with those determined for the free antibiotics. © 2020 by the authors. Licensee MDPI, Basel, Switzerland.
License of this version: CC BY 4.0 Unported
Document Type: Article
Publishing status: publishedVersion
Issue Date: 2020
Appears in Collections:Naturwissenschaftliche Fakultät

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1 image of flag of Germany Germany 36 63.16%
2 image of flag of United States United States 11 19.30%
3 image of flag of China China 6 10.53%
4 image of flag of No geo information available No geo information available 1 1.75%
5 image of flag of Taiwan Taiwan 1 1.75%
6 image of flag of United Kingdom United Kingdom 1 1.75%
7 image of flag of France France 1 1.75%

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