Methods for Health Economic Evaluation of Vaccines and Immunization Decision Frameworks: A Consensus Framework from a European Vaccine Economics Community

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dc.identifier.uri http://dx.doi.org/10.15488/1025
dc.identifier.uri http://www.repo.uni-hannover.de/handle/123456789/1049
dc.contributor.author Ultsch, Bernhard
dc.contributor.author Damm, Oliver
dc.contributor.author Beutels, Phillippe
dc.contributor.author Bilcke, Joke
dc.contributor.author Brüggenjürgen, Bernd
dc.contributor.author Gerber-Grote, Andreas
dc.contributor.author Greiner, Wolfgang
dc.contributor.author Hanquet, Germaine
dc.contributor.author Hutubessy, Raymond
dc.contributor.author Jit, Mark
dc.contributor.author Knol, Mirjam
dc.contributor.author Kries, Rüdiger von
dc.contributor.author Kuhlmann, Alexander
dc.contributor.author Levy-Bruhl, Daniel
dc.contributor.author Perleth, Matthias
dc.contributor.author Postma, Maarten
dc.contributor.author Salo, Heini
dc.contributor.author Siebert, Uwe
dc.contributor.author Wasem, Jürgen
dc.contributor.author Wichmann, Ole
dc.date.accessioned 2017-01-12T08:11:11Z
dc.date.available 2017-01-12T08:11:11Z
dc.date.issued 2016
dc.identifier.citation Ultsch, B.; Damm, O.; Beutels, P.; Bilcke, J.; Brüggenjürgen, B. et al.: Methods for Health Economic Evaluation of Vaccines and Immunization Decision Frameworks: A Consensus Framework from a European Vaccine Economics Community. In: PharmacoEconomics 34 (2016), Nr. 3, S. 227-244. DOI: http://dx.doi.org/10.1007/s40273-015-0335-2
dc.description.abstract Background: Incremental cost-effectiveness and cost-utility analyses [health economic evaluations (HEEs)] of vaccines are routinely considered in decision making on immunization in various industrialized countries. While guidelines advocating more standardization of such HEEs (mainly for curative drugs) exist, several immunization-specific aspects (e.g. indirect effects or discounting approach) are still a subject of debate within the scientific community. Objective: The objective of this study was to develop a consensus framework for HEEs of vaccines to support the development of national guidelines in Europe. Methods: A systematic literature review was conducted to identify prevailing issues related to HEEs of vaccines. Furthermore, European experts in the field of health economics and immunization decision making were nominated and asked to select relevant aspects for discussion. Based on this, a workshop was held with these experts. Aspects on ‘mathematical modelling’, ‘health economics’ and ‘decision making’ were debated in group-work sessions (GWS) to formulate recommendations and/or—if applicable—to state ‘pros’ and ‘contras’. Results: A total of 13 different aspects were identified for modelling and HEE: model selection, time horizon of models, natural disease history, measures of vaccine-induced protection, duration of vaccine-induced protection, indirect effects apart from herd protection, target population, model calibration and validation, handling uncertainty, discounting, health-related quality of life, cost components, and perspectives. For decision making, there were four aspects regarding the purpose and the integration of HEEs of vaccines in decision making as well as the variation of parameters within uncertainty analyses and the reporting of results from HEEs. For each aspect, background information and an expert consensus were formulated. Conclusions: There was consensus that when HEEs are used to prioritize healthcare funding, this should be done in a consistent way across all interventions, including vaccines. However, proper evaluation of vaccines implies using tools that are not commonly used for therapeutic drugs. Due to the complexity of and uncertainties around vaccination, transparency in the documentation of HEEs and during subsequent decision making is essential. © 2015, The Author(s). eng
dc.description.sponsorship Federal Ministry of Health Germany
dc.language.iso eng
dc.publisher New York : Springer International Publishing
dc.relation.ispartofseries PharmacoEconomics 34 (2016), Nr. 3
dc.rights CC BY-NC 4.0
dc.rights.uri https://creativecommons.org/licenses/by-nc/4.0/
dc.subject health economic evaluation eng
dc.subject HEE eng
dc.subject health economics eng
dc.subject.ddc 610 | Medizin, Gesundheit ger
dc.subject.ddc 330 | Wirtschaft ger
dc.title Methods for Health Economic Evaluation of Vaccines and Immunization Decision Frameworks: A Consensus Framework from a European Vaccine Economics Community
dc.type Text
dc.type article
dc.relation.essn 1179-2027
dc.relation.issn 1170-7690
dc.relation.doi https://doi.org/10.1007/s40273-015-0335-2
dc.bibliographicCitation.issue 3
dc.bibliographicCitation.volume 34
dc.bibliographicCitation.firstPage 227
dc.bibliographicCitation.lastPage 244
dc.description.version publishedVersion
tib.accessRights frei zug�nglich


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