Methods for Health Economic Evaluation of Vaccines and Immunization Decision Frameworks: A Consensus Framework from a European Vaccine Economics Community

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Ultsch, B.; Damm, O.; Beutels, P.; Bilcke, J.; Brüggenjürgen, B. et al.: Methods for Health Economic Evaluation of Vaccines and Immunization Decision Frameworks: A Consensus Framework from a European Vaccine Economics Community. In: PharmacoEconomics 34 (2016), Nr. 3, S. 227-244. DOI: http://dx.doi.org/10.1007/s40273-015-0335-2

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Sum total of downloads: 180




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Abstract: 
Background: Incremental cost-effectiveness and cost-utility analyses [health economic evaluations (HEEs)] of vaccines are routinely considered in decision making on immunization in various industrialized countries. While guidelines advocating more standardization of such HEEs (mainly for curative drugs) exist, several immunization-specific aspects (e.g. indirect effects or discounting approach) are still a subject of debate within the scientific community. Objective: The objective of this study was to develop a consensus framework for HEEs of vaccines to support the development of national guidelines in Europe. Methods: A systematic literature review was conducted to identify prevailing issues related to HEEs of vaccines. Furthermore, European experts in the field of health economics and immunization decision making were nominated and asked to select relevant aspects for discussion. Based on this, a workshop was held with these experts. Aspects on ‘mathematical modelling’, ‘health economics’ and ‘decision making’ were debated in group-work sessions (GWS) to formulate recommendations and/or—if applicable—to state ‘pros’ and ‘contras’. Results: A total of 13 different aspects were identified for modelling and HEE: model selection, time horizon of models, natural disease history, measures of vaccine-induced protection, duration of vaccine-induced protection, indirect effects apart from herd protection, target population, model calibration and validation, handling uncertainty, discounting, health-related quality of life, cost components, and perspectives. For decision making, there were four aspects regarding the purpose and the integration of HEEs of vaccines in decision making as well as the variation of parameters within uncertainty analyses and the reporting of results from HEEs. For each aspect, background information and an expert consensus were formulated. Conclusions: There was consensus that when HEEs are used to prioritize healthcare funding, this should be done in a consistent way across all interventions, including vaccines. However, proper evaluation of vaccines implies using tools that are not commonly used for therapeutic drugs. Due to the complexity of and uncertainties around vaccination, transparency in the documentation of HEEs and during subsequent decision making is essential. © 2015, The Author(s).
License of this version: CC BY-NC 4.0
Document Type: Text
Publishing status: publishedVersion
Issue Date: 2016
Appears in Collections:Wirtschaftswissenschaftliche Fakultät

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pos. country downloads
total perc.
1 image of flag of Germany Germany 83 46.11%
2 image of flag of United States United States 39 21.67%
3 image of flag of No geo information available No geo information available 10 5.56%
4 image of flag of Russian Federation Russian Federation 10 5.56%
5 image of flag of France France 8 4.44%
6 image of flag of Netherlands Netherlands 4 2.22%
7 image of flag of Hong Kong Hong Kong 3 1.67%
8 image of flag of United Kingdom United Kingdom 3 1.67%
9 image of flag of Switzerland Switzerland 3 1.67%
10 image of flag of Mexico Mexico 2 1.11%
    other countries 15 8.33%

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