Piled rafts have been used as a foundation system for high-rise buildings worldwide in different soil conditions, e.g., in soft to stiff clay as well as in medium-to-dense sand. Piled raft is currently used not only to control the foundation settlement but also to minimize the required raft thickness to reach the most optimized foundation design. The purpose of this study is to investigate the behavior of piled raft as a foundation system for Frankfurt over-consolidated clay based on the well-monitored Messeturm building in Germany. The numerical tool used in analysis is Plaxis 3D finite element software with hardening soil material model. The piled raft foundation behavior will be evaluated based on the total settlement, differential settlement and the pile skin friction. Based on this study, it was found that the chosen foundation system “plied raft foundation” for Messeturm was an optimized solution for the proposed building.