Functional diversity of AAA+ protease complexes in Bacillus subtilis

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Elsholz, A.K.W.; Birk, M.S.; Charpentier, E.; Turgay, K.: Functional diversity of AAA+ protease complexes in Bacillus subtilis. In: Frontiers in Molecular Biosciences 4 (2017), 44. DOI: https://doi.org/10.3389/fmolb.2017.00044

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Sum total of downloads: 37




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Abstract: 
Here, we review the diverse roles and functions of AAA+ protease complexes in protein homeostasis, control of stress response and cellular development pathways by regulatory and general proteolysis in the Gram-positive model organism Bacillus subtilis. We discuss in detail the intricate involvement of AAA+ protein complexes in controlling sporulation, the heat shock response and the role of adaptor proteins in these processes. The investigation of these protein complexes and their adaptor proteins has revealed their relevance for Gram-positive pathogens and their potential as targets for new antibiotics. © 2017 Elsholz, Birk, Charpentier and Turgay.
License of this version: CC BY 4.0
Document Type: article
Publishing status: publishedVersion
Issue Date: 2017
Appears in Collections:Naturwissenschaftliche Fakultät

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1 image of flag of Germany Germany 35 94.59%
2 image of flag of France France 1 2.70%
3 image of flag of Estonia Estonia 1 2.70%

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