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Originalpublikation
Elsholz, A.K.W.; Birk, M.S.; Charpentier, E.; Turgay, K.: Functional diversity of AAA+ protease complexes in Bacillus subtilis. In: Frontiers in Molecular Biosciences 4 (2017), 44. DOI: https://doi.org/10.3389/fmolb.2017.00044
Version im Repositorium
Zum Zitieren der Version im Repositorium verwenden Sie bitte diesen DOI:
https://doi.org/10.15488/3340
| Zusammenfassung: | |
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Here, we review the diverse roles and functions of AAA+ protease complexes in protein homeostasis, control of stress response and cellular development pathways by regulatory and general proteolysis in the Gram-positive model organism Bacillus subtilis. We discuss in detail the intricate involvement of AAA+ protein complexes in controlling sporulation, the heat shock response and the role of adaptor proteins in these processes. The investigation of these protein complexes and their adaptor proteins has revealed their relevance for Gram-positive pathogens and their potential as targets for new antibiotics. © 2017 Elsholz, Birk, Charpentier and Turgay.
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| Lizenzbestimmungen: | CC BY 4.0 Unported - https://creativecommons.org/licenses/by/4.0/ |
| Publikationstyp: | Article |
| Publikationsstatus: | publishedVersion |
| Erstveröffentlichung: | 2017 |
| Schlagwörter (englisch): | AAA+ protease complexes, Adaptor proteins, Bacillus subtilis, Chaperones, Hsp100/Clp proteins, McsB, Protein quality control, Regulatory proteolysis |
| Fachliche Zuordnung (DDC): | 570 | Biowissenschaften, Biologie |
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