New multi-material manufacturing technologies demand the development of new mechanical designapproaches, as seen in the production of hybrid components through Tailored Forming. Thereby, a newclass of high-performance multi-material parts aiming for enhanced properties, such as lightweight properties,can be constructed and brings with it new challenges. The objective of this paper is to develop amethod for finding the optimal material distribution for such multi-material components. Thereunto,Topology Optimization techniques were reviewed, focusing on the progress made on multi-materialsand manufacturing constraints implementations. Following, a new method was developed and analyzed,called Interfacial Zone Evolutionary Optimization (IZEO), and here expanded for a multi-materialapproach. This method makes use of the Evolutionary Algorithms methodology to solve structural optimizationproblems and provides a flexible way to implement manufacturing constraints. Finally, somecases are presented, in which the developed tool was able to generate a multi-material and manufacturablehigh-performance design.