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Aptamer-modified polymer nanoparticles for targeted drug delivery

Modrejewski, Julia; Walter, Johanna-Gabriela; Kretschmer, Imme; Kemal, Evren; Green, Mark; Belhadj, Hamza; Blume, Cornelia; Scheper, Thomas (Berlin : De Gruyter, 2016)

The purpose of this study was to develop a model system for targeted drug delivery. This system should enable targeted drug release at a certain tissue in the body. In conventional drug delivery systems, drugs are often ...
Biodegradation of a magnesium alloy implant in the intercondylar femoral notch showed an appropriate response to the synovial membrane in a rabbit model in vivo

Ezechieli, Marco; Diekmann, Julia; Weizbauer, Andreas; Becher, Christoph; Willbold, Elmar; Helmecke, Patrick; Lucas, Arne; Schavan, Robert; Windhagen, Henning (London : SAGE Publications Ltd., 2014)

Degradable magnesium alloys are promising biomaterials for orthopedic applications. The aim of this study was to evaluate the potential effects on both the synovial membrane (synovialis) and the synovial fluid (synovia) ...
Biofunctional quantum dots as fluorescence probe for cell-specific targeting

Ag, Didem; Bongartz, Rebecca; Dogan, Leyla Eral; Seleci, Muharrem; Walter, Johanna-Gabriela; Demirkol, Dilek Odaci; Stahl, Frank; Ozcelik, Serdar; Timur, Suna; Scheper, Thomas (Amsterdam : Elsevier, 2014)

We describe here the synthesis, characterization, bioconjugation, and application of water-soluble thioglycolic acid TGA-capped CdTe/CdS quantum dots (TGA-QDs) for targeted cellular imaging. Anti-human epidermal growth ...
Biologic TNF inhibiting agents for treatment of inflammatory rheumatic diseases: Dosing patterns and related costs in Switzerland from a payers perspective

Zeidler, Jan; Mittendorf, Thomas; Müller, Rüdiger; Kempis, Johannes von (Heidelberg : Springer Verlag, 2012)

Background: To obtain detailed real-life data on costs and dosing patterns in the utilisation of the TNF inhibitors adalimumab, etanercept, and infliximab in patients treated in Switzerland. Methods: Administrative claims ...
Blue native DIGE as a tool for comparative analyses of protein complexes

Heinemeyer, Jesco; Scheibe, Burghardt; Schmitz, Udo K.; Braun, Hans-Peter (New York, NY [u.a.] : Elsevier, 2009)

Differential gel electrophoresis (DIGE) is based on pre-labeling of different protein fractions and their subsequent co-electrophoresis in a single gel. Cyanine based "CyDye DIGE Fluor minimal dyes" are used for the labeling ...
Carbonic anhydrase subunits form a matrix-exposed domain attached to the membrane arm of mitochondrial complex I in plants

Sunderhaus, Stephanie; Dudkina, Natalya V.; Jänsch, Lothar; Klodmann, Jennifer; Heinemeyer, Jesco; Perales, Mariano; Zabaleta, Eduardo; Boekema, Egbert J.; Braun, Hans-Peter (Bethesda, Md. : ASBMB Publications, 2006)

Complex I of Arabidopsis includes five structurally related subunits representing γ-type carbonic anhydrases termed CA1, CA2, CA3, CAL1, and CAL2. The position of these subunits within complex I was investigated. Direct ...
CEDAR, an online resource for the reporting and exploration of complexome profiling data

van Strien, Joeri; Haupt, Alexander S.; Schulte, Uwe; Braun, Hans-Peter; Cabrera-Orefice, Alfredo; Choudhary, Jyoti S.; Evers, Felix; Fernandez-Vizarra, Erika; Guerrero-Castillo, Sergio; Kooij, Taco W.A.; Páleníková, Petra; Pardo, Mercedes; Ugalde, Cristina; Wittig, Ilka; Wöhlbrand, Lars; Brandt, Ulrich; Arnold, Susanne; Huynen, Martijn A. (Amsterdam : Elsevier, 2021)

Complexome profiling is an emerging ‘omics’ approach that systematically interrogates the composition of protein complexes (the complexome) of a sample, by combining biochemical separation of native protein complexes with ...
Characterization of the bifunctional cytochrome c reductase-processing peptidase complex from potato mitochondria

Emmermann, M.; Braun, Hans-Peter; Arretz, M.; Schmitz, U.K. (Bethesda, Md. : ASBMB Publications, 1993)

In potato, cytochrome c reductase, a protein complex of the respiratory chain, exhibits processing activity toward mitochondrial precursor proteins. One of the two cooperating components of the processing peptidase was ...
Comparative in vitro study and biomechanical testing of two different magnesium alloys

Weizbauer, Andreas; Modrejewski, Christian; Behrens, Sabine; Klein, Helmut; Helmecke, Patrick; Seitz, Jan-Marten; Windhagen, Henning; Möhwald, Kai; Reifenrath, Janin; Waizy, Hazibullah (London : SAGE Publications Ltd., 2014)

In this in vitro study, magnesium plates of ZEK100 and MgCa0.8 alloy similar to common titanium alloy osteosynthesis plates were investigated as degradable biomedical materials with a focus on primary stability. Immersion ...
Comparison of colorimetric methods for the quantification of model proteins in aqueous two-phase systems

Glyk, Anna; Heinisch, Sandra L.; Scheper, Thomas; Beutel, Sascha (Cambridge, MA : Elsevier Academic Press, 2015)

In the current study, the quantification of different model proteins in the presence of typical aqueous two-phase system components was investigated by using the Bradford and bicinchoninic acid (BCA) assays. Each phase-forming ...
Complexome profiling reveals association of PPR proteins with ribosomes in the mitochondria of plants

Rugen, Nils; Straube, Henryk; Franken, Linda E.; Braun, Hans-Peter; Eubel, Holger (Bethesda, Md. : The American Society for Biochemistry and Molecular Biology, 2019)

Mitochondrial transcripts are subject to a wealth of processing mechanisms including cis- and trans-splicing events, as well as base modifications (RNA editing). HUndreds of proteins are required for these processes in ...
Consent for Biobanking: The Legal Frameworks of Countries in the BioSHaRE-EU Project

Kaye, Jane; Briceño Moraia, Linda; Curren, Liam; Bell, Jessica; Mitchell, Colin; Soini, Sirpa; Hoppe, Nils; Øien, Morten; Rial-Sebbag, Emmanuelle (New Rochelle, NY : Liebert, 2016)

Currently, there is no single, Europe-wide regulation of biomedical research using human samples and data. Instead, the law that applies spans a number of areas of law, such as data protection, clinical trials, and tissue ...
Considerations about the effectiveness and cost effectiveness of therapies in the treatment of hyperphosphataemia

Plagemann, Thomas; Prenzler, Anne; Mittendorf, Thomas (Heidelberg : Springer Verlag, 2011)

Because of an elevated serum phosphate level, patients who suffer from chronic kidney failure frequently tend to have cardiovascular calcification and are therefore exposed to a higher probability of a fatal event. Phosphate ...
Cost effectiveness of exemestane versus tamoxifen in post-menopausal women with early breast cancer in Germany

Braun, Sebastian; Mittendorf, Thomas; Menschik, Thomas; Greiner, Wolfgang; Schulenburg, Johann-Matthias Graf von der (Basel : S. Karger AG, 2009)

Background: Medical studies have shown that switching to exemestane after 2-3 years of adjuvant treatment with tamoxifen is effective when looking at overall survival. No cost effectiveness study of exemestane has been ...
Cost-effectiveness of population-based genetic hemochromatosis screening

Schöffski, Oliver; Schmidtke, Jörg; Stuhrmann, Manfred (Basel: S. Karger, 2000)

Objective: Evaluation of the costs of a population-based genetic hemochromatosis (HH) screening. Methods: We performed a decision tree analysis and subsequently quantified the screening and treatment costs and the effect ...
Costs and treatment patterns of incident ADHD patients - a comparative analysis before and after the initial diagnosis -

Klora, Mike; Zeidler, Jan; Linder, Roland; Verheyen, Frank; Schulenburg, Johann-Matthias Graf von der (Heidelberg : Springer Verlag, 2015)

Background and objectives: The costs and treatment patterns of attention deficit hyperactivity disorder (ADHD) are subjects of health services research in Germany and worldwide. Previous publications focused mainly on ...
The costs of schizophrenia and predictors of hospitalisation from the statutory health insurance perspective

Zeidler, Jan; Slawik, Lara; Fleischmann, Jochen; Greiner, Wolfgang (Heidelberg : Springer Verlag, 2012)

Background: The aim of the study was to determine the costs of treating schizophrenia from the perspective of the statutory health insurance, as well as the identification of predictors of hospitalisation of formerly stable ...
Diet-dependent net endogenous acid load of vegan diets in relation to food groups and bone health-related nutrients: Results from the German Vegan Study

Ströhle, Alexander; Waldmann, Annika; Koschizke, Jochen; Leitzmann, Claus; Hahn, Andreas (Basel : S. Karger AG, 2011)

Background/Aims:Dietary composition has been shown to affect acid-base homeostasis and bone health in humans. We investigated the potential renal acid load (PRAL) and the estimated diet-dependent net acid load (net endogenous ...
Dietary intake of vitamin B6 and concentration of vitamin B 6 in blood samples of German vegans

Waldmann, A.; Dörr, B.; Koschizke, J.W.; Leitzmann, C.; Hahn, A. (Cambridge : Cambridge University Press, 2006)

Objective: The study aimed to evaluate the dietary vitamin B6 intake and determine the vitamin B6 concentration in blood samples of German vegans. Design and setting: Cross-sectional study with 33 examination sites all ...
Dietary iron intake and iron status of German female vegans: Results of the German Vegan Study

Waldmann, Annika; Koschizke, Jochen W.; Leitzmann, Claus; Hahn, Andreas (Basel : S. Karger AG, 2004)

Background: As shown in previous studies vegetarians and especially vegans are at risk for iron deficiency. Our study evaluated the iron status of German female vegans. Methods: In this cross-sectional study, the dietary ...

Now showing items 1-20 of 76

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