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Browsing by Subject "major clinical study"

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Abdominal obesity‐related disturbance of insulin sensitivity is associated with cd8+ emra cells in the elderly

Boßlau, Tim K.; Wasserfurth, Paulina; Krüger, Britta; Reichel, Thoma; Palmowski, Jana; Nebl, Josefine; Weyh, Christopher; Schenk, Alexander; Joisten, Niklas; Stahl, Frank; Thoms, Stefanie; Gebhardt, Kristina; Hahn, Andreas; Krüger, Karsten (Basel : MDPI, 2021)

Aging and overweight increase the risk of developing type 2 diabetes mellitus. In this cross‐sectional study, we aimed to investigate the potential mediating role of T‐EMRA cells and inflammatory markers in the development ...
Biologic TNF inhibiting agents for treatment of inflammatory rheumatic diseases: Dosing patterns and related costs in Switzerland from a payers perspective

Zeidler, Jan; Mittendorf, Thomas; Müller, Rüdiger; Kempis, Johannes von (Heidelberg : Springer Verlag, 2012)

Background: To obtain detailed real-life data on costs and dosing patterns in the utilisation of the TNF inhibitors adalimumab, etanercept, and infliximab in patients treated in Switzerland. Methods: Administrative claims ...
Converging or Crossing Curves: Untie the Gordian Knot or Cut it? Appropriate Statistics for Non-Proportional Hazards in Decitabine DACO-016 Study (AML)

Tomeczkowski, Jörg; Lange, Ansgar; Güntert, Andreas; Thilakarathne, Pushpike; Diels, Joris; Xiu, Liang; De Porre, Peter; Tapprich, Christoph (New York : Springer Healthcare, 2015)

Introduction: Among patients with acute myeloid leukemia (AML), the DACO-016 randomized study showed reduction in mortality for decitabine [Dacogen® (DAC), Eisai Inc., Woodcliff Lake, NJ, USA] compared with treatment ...
Cost-effectiveness of primarily human papillomavirus-based cervical cancer screening in settings with currently established Pap screening: A systematic review commissioned by the German Federal Ministry of Health

Mühlberger, Nikolai; Sroczynski, Gaby; Esteban, Eva; Mittendorf, Thomas; Miksad, Rebecca A.; Siebert, Uwe (Cambridge : Cambridge University Press, 2008)

Objectives: The aim of this study was to summarize the current evidence for the cost-effectiveness of primarily human papillomavirus (HPV) -based cervical cancer screening in settings with already established Papanicolaou ...
Costs and treatment patterns of incident ADHD patients - a comparative analysis before and after the initial diagnosis -

Klora, Mike; Zeidler, Jan; Linder, Roland; Verheyen, Frank; Schulenburg, Johann-Matthias Graf von der (Heidelberg : Springer Verlag, 2015)

Background and objectives: The costs and treatment patterns of attention deficit hyperactivity disorder (ADHD) are subjects of health services research in Germany and worldwide. Previous publications focused mainly on ...
The costs of schizophrenia and predictors of hospitalisation from the statutory health insurance perspective

Zeidler, Jan; Slawik, Lara; Fleischmann, Jochen; Greiner, Wolfgang (Heidelberg : Springer Verlag, 2012)

Background: The aim of the study was to determine the costs of treating schizophrenia from the perspective of the statutory health insurance, as well as the identification of predictors of hospitalisation of formerly stable ...
Einflussfaktoren auf die Standortwahl von hausärztlichen Land- und Stadtärzten in Niedersachsen

Schmidt, Katharina; Marten, Ole; Kühne, Christina; Zeidler, Jan; Frank, Martin (Stuttgart : Thieme, 2017)

Background and aim: The overall distribution and appropriate general practitioner (GP) supply is an increasing challenge. Therefore, the analysis of priorities and factors regarding the location of GPs’ practice is of major ...
German vegan study: Diet, life-style factors, and cardiovascular risk profile

Waldmann, A.; Koschizke, J.W.; Leitzmann, C.; Hahn, A. (Basel : S. Karger AG, 2005)

Background/Aim: Evaluation of cardiovascular risk profile in 154 German vegans. Methods: Cross-sectional study, Germany. Study instruments: 2 FFQ, 2 questionnaires, analyses of fasting venous blood samples. Results: The ...
High unawareness of chronic kidney disease in Germany

Stolpe, Susanne; Kowall, Bernd; Scholz, Christian; Stang, Andreas; Blume, Cornelia (Basel : MDPI, 2021)

Chronic kidney disease (CKD) is associated with an increased risk for cardiovascular events, hospitalizations, end stage renal disease and mortality. Main risk factors for CKD are diabetes, hypertension, and older age. ...
Influence of combined functional resistance and endurance exercise over 12 weeks on matrix metalloproteinase-2 serum concentration in persons with relapsing-remitting multiple sclerosis-a community-based randomized controlled trial

Proschinger, Sebastian; Joisten, Niklas; Rademacher, Annette; Schlagheck, Marit L.; Walzik, David; Metcalfe, Alan J.; Oberste, Max; Warnke, Clemens; Bloch, Wilhelm; Schenk, Alexander; Bansi, Jens; Zimmer, Philipp (London : BioMed Central Ltd., 2019)

Background: The relevance of regular moderate to intense exercise for ameliorating psychomotor symptoms in persons with multiple sclerosis (pwMS) is becoming increasingly evident. Over the last two decades, emerging evidence ...
Mitochondrial haplogroup analysis in colorectal cancer: Identification of a high-risk population

Akouchekian, M.; Houshmand, M. (Poznan : Termedia Publishing House, 2008)

Introduction: Colorectal cancer is the third most common type of non-skin cancer in men (after prostate and Lung cancer) and women (after breast and Lung cancer). The mitochondrion conventionally is often thought to be an ...
Monocyte chemotactic protein-1 as a potential biomarker for early anti-thrombotic therapy after ischemic stroke

Worthmann, Hans; Dengler, Reinhard; Schumacher, Helmut; Schwartz, Andreas; Eisert, Wolfgang G.; Lichtinghagen, Ralf; Weissenborn, Karin (Basel : MDPI AG, 2012)

Inflammation following ischemic brain injury is correlated with adverse outcome. Preclinical studies indicate that treatment with acetylsalicylic acid + extended-release dipyridamole (ASA + ER-DP) has anti-inflammatory and ...
A multinational economic evaluation of rhDNase in the treatment of cystic fibrosis

Menzin, Joseph; Oster, Gerry; Davies, Linda; Drummond, Michael F.; Greiner, Wolfgang; Lucioni, Carlo; Merot, Jean-Luis; Rossi, Franco; Schulenburg, Johann-Matthias Graf von der; Souêtre, Eric (Cambridge : Cambridge University Press, 1996)

Economic evaluations of pharmaceuticals are increasingly being conducted in conjunction with randomized phase III clinical trials to meet the demand for pharmacoeconomic data when new products are launched. While the need ...
Occurrence of large-scale mitochondrial DNA deletions in human colorectal cancer

Akouchekian, Mansoureh; Houshmand, Massoud; Hemati, Simin; Shafa, Mehdi (Poznan : Termedia Publishing House, 2008)

Introduction: The aim of this study was to determine the mutation patterns of colon cancers through screening of different regions of mitochondrial DNA (mtDNA) in colon cancer patients. Material and methods: In order to ...
Prediction of child and adolescent outcomes with broadband and narrowband dimensions of internalizing and externalizing behavior using the child and adolescent version of the Strengths and Difficulties Questionnaire

Kulawiak, Pawel R.; Wilbert, Jürgen; Schlack, Robert; Börnert-Ringleb, Moritz (San Francisco, Ca. : PLOS, 2020)

The Strengths and Difficulties Questionnaire (SDQ) is a frequently used screening instrument for behavioral problems in children and adolescents. There is an ongoing controversy -not only in educational research-regarding ...
Regional differences in health care of patients with inflammatory bowel disease in Germany

Lange, Ansgar; Prenzler, Anne; Bachmann, Oliver; Linder, Roland; Neubauer, Sarah; Zeidler, Jan; Manns, Michael P.; Schulenburg, Johann-Matthias Graf von der (Heidelberg : Springer Verlag, 2015)

Background: The regional availability of specialized physicians is an important aspect in healthcare of patients with IBD. The association between physician density and healthcare is not yet clear. Most studies did not ...
The socioeconomic profile of patients treated by phlebotropic drugs in Germany

Uber, Andrea (London : SAGE Publications Ltd., 1997)

Conservative treatment of venous disease is difficult. There is much skepticism concerning the efficacy of drugs in venous diseases. Nevertheless, in Germany, these drugs have obtained a substantial market share with a ...
Telemonitoring-Supported Exercise Training in Employees With Metabolic Syndrome Improves Liver Inflammation and Fibrosis

Haufe, Sven; Hupa-Breier, Katharina L.; Bayerle, Pauline; Boeck, Hedwig T.; Rolff, Simone; Sundermeier, Thorben; Kerling, Arno; Eigendorf, Julian; Kück, Momme; Hanke, Alexander A.; Ensslen, Ralf; Nachbar, Lars; Lauenstein, Dirk; Böthig, Dietmar; Hilfiker-Kleiner, Denise; Stiesch, Meike; Terkamp, Christoph; Wedemeyer, Heiner; Haverich, Axel; Tegtbur, Uwe (London : Nature Publ. Group, 2021)

INTRODUCTION:Metabolic syndrome (MetS) is a major health problem worldwide and the main risk factor for metabolic-associated fatty liver disease (MAFLD). Established treatment options are lifestyle interventions facilitating ...
The economic impact and health-related quality of life of spinal muscular atrophy. An analysis across europe

Peña-Longobardo, Luz María; Aranda-Reneo, Isaac; Oliva-Moreno, Juan; Litzkendorf, Svenja; Durand-Zaleski, Isabelle; Tizzano, Eduardo; López-Bastida, Julio (Basel : MDPI, 2020)

Background: this study aimed to estimate the economic impact and health-related quality of life (HRQOL) of patients with spinal muscular atrophy (SMA) in three European countries. It was used a cross-sectional study carried ...

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