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Originalpublikation
Boßlau, T.K.; Wasserfurth, P.; Krüger, B.; Reichel, T.; Palmowski, J. et al.: Abdominal obesity‐related disturbance of insulin sensitivity is associated with cd8+ emra cells in the elderly. In: Cells 10 (2021), Nr. 5, 998. DOI: https://doi.org/10.3390/cells10050998
Version im Repositorium
Zum Zitieren der Version im Repositorium verwenden Sie bitte diesen DOI:
https://doi.org/10.15488/12351
| Zusammenfassung: | |
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Aging and overweight increase the risk of developing type 2 diabetes mellitus. In this cross‐sectional study, we aimed to investigate the potential mediating role of T‐EMRA cells and inflammatory markers in the development of a decreased insulin sensitivity. A total of 134 healthy older volunteers were recruited (age 59.2 (SD 5.6) years). T cell subpopulations were analyzed by flow cytometry. Furthermore, body composition, HOMA‐IR, plasma tryptophan (Trp) metabolites, as well as cytokines and adipokines were determined. Using subgroup and covariance analyses, the influence of BMI on the parameters was evaluated. Moreover, correlation, multiple regression, and mediation analyses were performed. In the subgroup of participants with obesity, an increased proportion of CD8+EMRA cells and elevated concentrations of plasma kynurenine (KYN) were found compared to the lower‐weight subgroups. Linear regression analysis revealed that an elevated HOMA‐IR could be predicted by a higher proportion of CD8+EMRA cells and KYN levels. A mediation analysis showed a robust indirect effect of the Waist‐to‐hip ratio on HOMA‐IR mediated by CD8+EMRA cells. Thus, the deleterious effects of abdominal obesity on glucose metabolism might be mediated by CD8+EMRA cells in the elderly. Longitudinal studies should validate this assumption and analyze the suitability of CD8+EMRA cells as early predictors of incipient prediabetes. © 2021 by the authors. Licensee MDPI, Basel, Switzerland.
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| Lizenzbestimmungen: | CC BY 4.0 Unported - https://creativecommons.org/licenses/by/4.0/ |
| Publikationstyp: | Article |
| Publikationsstatus: | publishedVersion |
| Erstveröffentlichung: | 2021 |
| Schlagwörter (englisch): | Elderly, Insulin resistance, Kynurenine pathway, Obesity, T‐EMRA cells, adipocytokine, adiponectin, cytokine, fractalkine, glucose, hemoglobin A1c, insulin, interleukin 1 receptor blocking agent, interleukin 15, interleukin 1beta, interleukin 6, kynurenine, resistin, tryptophan, tumor necrosis factor, adipocytokine, biological marker, cytokine, kynurenine, receptor type tyrosine protein phosphatase C, tryptophan, abdominal obesity, adult, Article, blood sampling, body composition, body mass, body weight, CD8+ T lymphocyte, cross-sectional study, Cytomegalovirus, enzyme linked immunosorbent assay, female, flow cytometry, glucose metabolism, hip circumference, HOMA index, homeostasis model assessment, human, human experiment, insulin resistance, insulin sensitivity, major clinical study, male, middle aged, normal human, peripheral blood mononuclear cell, T lymphocyte subpopulation, tryptophan metabolism, waist circumference, waist hip ratio, abdominal obesity, blood, case control study, CD8+ T lymphocyte, immunological memory, immunology, insulin resistance, metabolism, pathophysiology, Adipokines, Biomarkers, Body Mass Index, Case-Control Studies, CD8-Positive T-Lymphocytes, Cross-Sectional Studies, Cytokines, Female, Humans, Immunologic Memory, Insulin Resistance, Kynurenine, Leukocyte Common Antigens, Male, Middle Aged, Obesity, Abdominal, Tryptophan |
| Fachliche Zuordnung (DDC): | 570 | Biowissenschaften, Biologie |
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