Auflistung nach Autor/in "9e2ff2ed-280d-46d6-a902-35bd40adfecd"

Auflistung nach Autor/in "9e2ff2ed-280d-46d6-a902-35bd40adfecd"

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  • Abdominal obesity‐related disturbance of insulin sensitivity is associated with cd8+ emra cells in the elderly 
    Boßlau, Tim K.; Wasserfurth, Paulina; Krüger, Britta; Reichel, Thoma; Palmowski, Jana; Nebl, Josefine; Weyh, Christopher; Schenk, Alexander; Joisten, Niklas; Stahl, Frank; Thoms, Stefanie; Gebhardt, Kristina; Hahn, Andreas; Krüger, Karsten (Basel : MDPI, 2021)
    Aging and overweight increase the risk of developing type 2 diabetes mellitus. In this cross‐sectional study, we aimed to investigate the potential mediating role of T‐EMRA cells and inflammatory markers in the development ...
  • Aptamer mediated niosomal drug delivery 
    Seleci, Didem Ag; Seleci, Muharrem; Jochums, André; Walter, Johanna-Gabriela; Stahl, Frank; Scheper, Thomas (Cambridge : Royal Society of Chemistry, 2016)
    Development of nanoscale carrier systems for targeted drug delivery is crucial for cancer treatment. The current methods of drug delivery exhibit some problems such as lack of therapy efficiency at the desired parts of the ...
  • Aptamer Microarrays-Current Status and Future Prospects 
    Witt, Martin; Walter, Johanna-Gabriela; Stahl, Frank (Basel : MDPI AG, 2015)
    Microarray technologies are state of the art in biological research, which requires fast genome, proteome and transcriptome analysis technologies. Often antibodies are applied in protein microarrays as proteomic tools. ...
  • Aptasensors for small molecule detection 
    Walter, Johanna-Gabriela; Heilkenbrinker, Alexandra; Austerjost, Jonas; Timur, Suna; Stahl, Frank; Scheper, Thomas (Berlin : De Gruyter, 2012)
    Aptamers are single-stranded oligonucleotides composed of RNA or DNA that are able to bind their corresponding targets via molecular recognition. Thus, aptamers can be thought of as nucleic acidbased alternatives to ...
  • Biofunctional quantum dots as fluorescence probe for cell-specific targeting 
    Ag, Didem; Bongartz, Rebecca; Dogan, Leyla Eral; Seleci, Muharrem; Walter, Johanna-Gabriela; Demirkol, Dilek Odaci; Stahl, Frank; Ozcelik, Serdar; Timur, Suna; Scheper, Thomas (Amsterdam : Elsevier, 2014)
    We describe here the synthesis, characterization, bioconjugation, and application of water-soluble thioglycolic acid TGA-capped CdTe/CdS quantum dots (TGA-QDs) for targeted cellular imaging. Anti-human epidermal growth ...
  • A Chemical Chaperone Restores Connexin 26 Mutant Activity 
    Wang, Dahua; Wang, Hongling; Fan, Lu; Ludwig, Tobias; Wegner, Andre; Stahl, Frank; Harre, Jennifer; Warnecke, Athanasia; Zeilinger, Carsten (Washington, DC : ACS Publications, 2023)
    Mutations in connexin 26 (Cx26) cause hearing disorders of a varying degree. Herein, to identify compounds capable of restoring the function of mutated Cx26, a novel miniaturized microarray-based screening system was ...
  • Development of an aptamer-based affinity purification method for vascular endothelial growth factor 
    Lönne, Maren; Bolten, Svenja Nicolin; Lavrentieva, Antonina; Stahl, Frank; Scheper, Thomas; Walter, Johanna-Gabriela (Amsterdam : Elsevier B.V., 2015)
    Since aptamers bind their targets with high affinity and specificity, they are promising alternative ligands in protein affinity purification. As aptamers are chemically synthesized oligonucleotides, they can be easily ...
  • Different gene expression profiles in normo- and dyslipidemic men after fish oil supplementation: Results from a randomized controlled trial 
    Schmidt, Simone; Stahl, Frank; Mutz, Kai-Oliver; Scheper, Thomas; Hahn, Andreas; Schuchardt, Jan Philipp (London : BioMed Central Ltd., 2012)
    Background: Epidemiological studies have suggested the benefits of omega-3 polyunsaturated fatty acids (n-3 PUFAs) on cardiovascular health, but only limited data are available describing n-3 PUFA regulated pathways in ...
  • Fluorescence Masking Based Multifunctional Quantum Dots’ Assay for HSP90α Interactions Detection 
    Kishore, Anusha; Fan, Lu; Stahl, Frank; Reichel, Thomas; Krüger, Karsten; Zeilinger, Carsten (Basel : MDPI, 2023)
    HSP90α is one of the most common stress proteins in cells; hence, it is a good target for developing drugs and testing systems for cancer or physical stress levels in humans. Streptavidin conjugated quantum dots (Sav-QDs) ...
  • Identification of a Thyroid Hormone Binding Site in Hsp90 with Implications for Its Interaction with Thyroid Hormone Receptor Beta 
    Fan, Lu; Kishore, Anusha; Jansen-Olliges, Linda; Wang, Dahua; Stahl, Frank; Psathaki, Olympia Ekaterini; Harre, Jennifer; Warnecke, Athanasia; Weder, Julia; Preller, Matthias; Zeilinger, Carsten (Washington, DC : ACS Publications, 2022)
    While many proteins are known clients of heat shock protein 90 (Hsp90), it is unclear whether the transcription factor, thyroid hormone receptor beta (TRb), interacts with Hsp90 to control hormonal perception and signaling. ...
  • The Impact of Photobleaching on Microarray Analysis 
    Haar, Marcel von der; Preuss, John-Alexander; Haar, Kathrin von der; Lindner, Patrick; Scheper, Thomas; Stahl, Frank (Basel : MDPI AG, 2015)
    DNA-Microarrays have become a potent technology for high-throughput analysis of genetic regulation. However, the wide dynamic range of signal intensities of fluorophore-based microarrays exceeds the dynamic range of a ...
  • In-Vitro Application of Magnetic Hybrid Niosomes: Targeted siRNA-Delivery for Enhanced Breast Cancer Therapy 
    Maurer, Viktor; Altin, Selin; Ag Seleci, Didem; Zarinwall, Ajmal; Temel, Bilal; Vogt, Peter M.; Strauß, Sarah; Stahl, Frank; Scheper, Thomas; Bucan, Vesna; Garnweitner, Georg (Basel : MDPI, 2021)
    Even though the administration of chemotherapeutic agents such as erlotinib is clinically established for the treatment of breast cancer, its efficiency and the therapy outcome can be greatly improved using RNA interference ...
  • Investigations of the Toxic Effect of Silver Nanoparticles on Mammalian Cell Lines 
    Sambale, Franziska; Wagner, S.; Stahl, Frank; Khaydarov, R.R.; Scheper, Thomas; Bahnemann, Detlef W. (New York : Hindawi Publishing Corporation, 2015)
    Silver nanoparticles are widely used for many applications. In this study silver nanoparticles have been tested for their toxic effect on fibroblasts (NIH-3T3), on a human lung adenocarcinoma epithelial cell line (A-549), ...
  • Iterative Cellular Screening System for Nanoparticle Safety Testing 
    Sambale, Franziska; Stahl, Frank; Rüdinger, Ferdinand; Seliktar, Dror; Kasper, Cornelia; Bahnemann, Detlef W.; Scheper, Thomas (New York : Hindawi Publishing Corporation, 2015)
    Nanoparticles have the potential to exhibit risks to human beings and to the environment; due to the wide applications of nanoproducts, extensive risk management must not be neglected. Therefore, we have constructed a ...
  • Laser ablation-based one-step generation and bio-functionalization of gold nanoparticles conjugated with aptamers 
    Walter, Johanna-Gabriela; Petersen, Svea; Stahl, Frank; Scheper, Thomas; Barcikowski, Stephan (London : Biomed Central Ltd., 2010)
    Background: Bio-conjugated nanoparticles are important analytical tools with emerging biological and medical applications. In this context, in situ conjugation of nanoparticles with biomolecules via laser ablation in an ...
  • Living Cell Microarrays: An Overview of Concepts 
    Jonczyk, Rebecca; Kurth, Tracy; Lavrentieva, Antonina; Walter, Johanna-Gabriela; Scheper, Thomas; Stahl, Frank (Basel : MDPI AG, 2016)
    Living cell microarrays are a highly efficient cellular screening system. Due to the low number of cells required per spot, cell microarrays enable the use of primary and stem cells and provide resolution close to the ...
  • Low impact of regular PCR testing on presence at work site during the COVID-19 pandemic: experiences during an open observational study in Lower Saxony 2020-21 
    Seiler, Lisa K.; Stolpe, Susanne; Stanislawski, Nils; Stahl, Frank; Witt, Martin; Jonczyk, Rebecca; Heiden, Stefanie; Blume, Holger; Kowall, Bernd; Blume, Cornelia (London : BioMed Central, 2023)
    Background: Since social distancing during the COVID-19-pandemic had a profound impact on professional life, this study investigated the effect of PCR testing on on-site work. Methods: PCR screening, antibody testing, and ...
  • Lung Surfactant Accelerates Skin Wound Healing : A Translational Study with a Randomized Clinical Phase I Study 
    Mirastschijski, Ursula; Schwab, Igor; Coger, Vincent; Zier, Ulrich; Rianna, Carmela; He, Wei; Maedler, Kathrin; Kelm, Sørge; Radtke, Arlo; Belge, Gazanfer; Lindner, Patrick; Stahl, Frank; Scharpenberg, Martin; Lasota, Lukas; Timm, Jürgen (London : Nature Publishing Group, 2020)
    Lung surfactants are used for reducing alveolar surface tension in preterm infants to ease breathing. Phospholipid films with surfactant proteins regulate the activity of alveolar macrophages and reduce inflammation. ...
  • Microarray-based screening system identifies temperature-controlled activity of Connexin 26 that is distorted by mutations 
    Wang, Hongling; Stahl, Frank; Scheper, Thomas; Steffens, Melanie; Warnecke, Athanasia; Zeilinger, Carsten (Berlin : Springer Nature, 2019)
    Here, we show that human Connexin 26 (hCx26 or Cx26WT) hemichannel opening rapidly enables the transport of small molecules when triggered by temperature and by compensation of the Ca2+ blockade with EDTA. Point mutations ...
  • Mobile SARS‑CoV‑2 screening facilities for rapid deployment and university-based diagnostic laboratory 
    Stanislawski, Nils; Lange, Ferdinand; Fahnemann, Christian; Riggers, Christoph; Wahalla, Marc-Nils; Porr, Marc; Cholewa, Fabian; Jonczyk, Rebecca; Thoms, Stefanie; Witt, Martin; Stahl, Frank; Beutel, Sascha; Winkel, Andreas; Pott, Philipp-Cornelius; Stiesch, Meike; Paulsen, Mira; Melk, Anette; Lucas, Henning; Heiden, Stefanie; Blume, Holger; Blume, Cornelia (Weinheim : Wiley-VCH, 2023)
    The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic has created a public crisis. Many medical and public institutions and businesses went into isolation in response to the pandemic. Because SARS-CoV-2 ...