Sequential and Multiple Testing for Dose-Response Analysis

Abstract

For the analysis of dose-response relationship under the assumption of ordered alternatives several global trend tests are available. Furthermore, there are multiple test procedures which can identify doses as effective or even as minimally effective. In this paper it is shown that the principles of multiple comparisons and interim analyses can be combined inflexible and adaptive strategies for dose-response analyses; these procedures control the experimentwise error rate. © 2000, Drug Information Association. All rights reserved.