Free Bioverit® II implants coated with a nanoporous silica layer in a mouse ear model - A histological study

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dc.identifier.uri http://dx.doi.org/10.15488/3009
dc.identifier.uri http://www.repo.uni-hannover.de/handle/123456789/3039
dc.contributor.author Vogt, J.C.
dc.contributor.author Brandes, G.
dc.contributor.author Ehlert, N.
dc.contributor.author Behrens, P.
dc.contributor.author Nolte, I.
dc.contributor.author Mueller, P.P.
dc.contributor.author Lenarz, T.
dc.contributor.author Stieve, M.
dc.date.accessioned 2018-03-01T08:47:22Z
dc.date.available 2018-03-01T08:47:22Z
dc.date.issued 2009
dc.identifier.citation Vogt, J.C.; Brandes, G.; Ehlert, N.; Behrens, P.; Nolte, I. et al.: Free Bioverit® II implants coated with a nanoporous silica layer in a mouse ear model - A histological study. In: Journal of Biomaterials Applications 24 (2009), Nr. 2, S. 175-191. DOI: https://doi.org/10.1177/0885328208095469
dc.description.abstract The objective of this study is to evaluate the suitability of a mouse middle ear model for testing ossicular replacement materials. Twenty-four BALB/c mice are implanted with the bioglass-ceramic Bioverit® II which is coated with a silica-nanostructure or with plain Bioverit® II as a control. After 2, 6, and 12 weeks, 4 mice per group are sacrificed and both complete petrous bones are analyzed histologically. All implants revealed in situ an incipient growth of thin connective tissue layers over the surface, followed by a spreading of epithelial cells. The osseogenic response which is increasing with time is more intense in the coated Bioverit® II specimens. The absence of inflammatory cells suggests an excellent biocompatibility of the silica nano structure. As the results are comparable to a study with the same materials in rabbits, the mouse model described is highly suitable for evaluation of new ossicular replacement materials. Additionally, by gene expression analysis a more detailed insight into cellular interactions of the middle ear is offered. eng
dc.language.iso eng
dc.publisher London : SAGE Publications Ltd.
dc.relation.ispartofseries Journal of Biomaterials Applications 24 (2009), Nr. 2
dc.rights Es gilt deutsches Urheberrecht. Das Dokument darf zum eigenen Gebrauch kostenfrei genutzt, aber nicht im Internet bereitgestellt oder an Außenstehende weitergegeben werden. Dieser Beitrag ist aufgrund einer (DFG-geförderten) Allianz- bzw. Nationallizenz frei zugänglich.
dc.subject Biocompatibility eng
dc.subject Bioverit® II eng
dc.subject Histology eng
dc.subject Middle ear eng
dc.subject Mouse eng
dc.subject Silica-nanocoating eng
dc.subject BALB/c mice eng
dc.subject Bio-glass eng
dc.subject Cellular interaction eng
dc.subject Connective tissue layer eng
dc.subject Epithelial cells eng
dc.subject Gene expression analysis eng
dc.subject In-situ eng
dc.subject Inflammatory cells eng
dc.subject Middle ear eng
dc.subject Middle ears eng
dc.subject Mouse eng
dc.subject Mouse models eng
dc.subject Nanoporous silica eng
dc.subject Replacement materials eng
dc.subject Biocompatibility eng
dc.subject Biological radiation effects eng
dc.subject Gene expression eng
dc.subject Histology eng
dc.subject Materials testing eng
dc.subject Musculoskeletal system eng
dc.subject Nanostructures eng
dc.subject Silica eng
dc.subject bioglass eng
dc.subject biomaterial eng
dc.subject nanomaterial eng
dc.subject silicon dioxide eng
dc.subject animal eng
dc.subject animal model eng
dc.subject article eng
dc.subject Bagg albino mouse eng
dc.subject bone development eng
dc.subject ceramics eng
dc.subject chemistry eng
dc.subject comparative study eng
dc.subject female eng
dc.subject middle ear eng
dc.subject middle ear prosthesis eng
dc.subject mouse eng
dc.subject porosity eng
dc.subject rabbit eng
dc.subject time eng
dc.subject transplantation eng
dc.subject ultrastructure eng
dc.subject Animals eng
dc.subject Ceramics eng
dc.subject Coated Materials, Biocompatible eng
dc.subject Ear, Middle eng
dc.subject Female eng
dc.subject Mice eng
dc.subject Mice, Inbred BALB C eng
dc.subject Models, Animal eng
dc.subject Nanostructures eng
dc.subject Ossicular Prosthesis eng
dc.subject Osteogenesis eng
dc.subject Porosity eng
dc.subject Rabbits eng
dc.subject Silicon Dioxide eng
dc.subject Time Factors eng
dc.subject.ddc 610 | Medizin, Gesundheit ger
dc.title Free Bioverit® II implants coated with a nanoporous silica layer in a mouse ear model - A histological study
dc.type article
dc.type Text
dc.relation.issn 0885-3282
dc.relation.doi https://doi.org/10.1177/0885328208095469
dc.bibliographicCitation.issue 2
dc.bibliographicCitation.volume 24
dc.bibliographicCitation.firstPage 175
dc.bibliographicCitation.lastPage 191
dc.description.version publishedVersion
tib.accessRights frei zug�nglich


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