Zusammenfassung: | |
Magnesium alloys have been investigated in different fields of medicine and represent a promising biomaterial for implants due to characteristics like bioabsorbability and osteoinduction. The objective of this study was to evaluate the usability of magnesium as implant material in middle ear surgery. Magnesium implants were placed into the right middle ear of eighteen New Zealand White rabbits. Nine animals were euthanized after four weeks and nine animals after three month. The petrous bones were removed and embedded in epoxy resin. The specimens were then polished, stained and evaluated with the aid of a light microscope. The histological examination revealed a good biocompatibility. After four weeks, a beginning corrosion of the implant's surface and low amount of trabecular bone formation in the area of the stapes base plate was observed. A considerable degradation of implants and obvious bone formation was found three month after implantation. The magnesium alloy used in the present study partly corroded too fast, so that a complete bone reconstruction could not be established in time. The increased osteoinduction on the stapes base plate resulted in a tight bone-implant bonding. Thus, a promising application of magnesium could be a coating of biomaterials in order to improve the bony integration of implants. © The Author(s) 2012 Reprints and permissions: sagepub.co.uk/journalsPermissions.nav.
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Lizenzbestimmungen: | Es gilt deutsches Urheberrecht. Das Dokument darf zum eigenen Gebrauch kostenfrei genutzt, aber nicht im Internet bereitgestellt oder an Außenstehende weitergegeben werden. Dieser Beitrag ist aufgrund einer (DFG-geförderten) Allianz- bzw. Nationallizenz frei zugänglich. |
Publikationstyp: | Article |
Publikationsstatus: | publishedVersion |
Erstveröffentlichung: | 2014 |
Schlagwörter (englisch): | Animal model, biodegradation, magnesium alloy, middle ear, osteoinduction, Animal model, Bioabsorbable magnesium, Bone reconstruction, Histological examination, Implant materials, Middle ears, New Zealand White rabbit, Osteoinduction, Animals, Biocompatibility, Biodegradation, Biological materials, Bone, Epoxy resins, Implants (surgical), Magnesium, Plates (structural components), Magnesium alloys, alloy, epoxy resin, magnesium, animal experiment, animal tissue, article, auditory ossicle, biocompatibility, biodegradation, bone implant, bone remodeling, cochlear nerve, controlled study, corrosion, experimental rabbit, external auditory canal, female, head tilting, implant, implantation, in vivo study, inflammation, microscopy, middle ear prosthesis, middle ear surgery, nerve injury, nonhuman, nystagmus, ossification, petrous bone, priority journal, stapes, surface property, trabecular bone, wound healing impairment, Animal model, biodegradation, magnesium alloy, middle ear, osteoinduction, Alloys, Animals, Biocompatible Materials, Female, Magnesium, Ossicular Prosthesis, Rabbits |
Fachliche Zuordnung (DDC): | 610 | Medizin, Gesundheit |
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