dc.identifier.uri |
http://dx.doi.org/10.15488/2697 |
|
dc.identifier.uri |
http://www.repo.uni-hannover.de/handle/123456789/2723 |
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dc.contributor.author |
Breithaupt, Dietmar E.
|
|
dc.contributor.author |
Weller, Philipp
|
|
dc.contributor.author |
Wolters, Maike
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|
dc.contributor.author |
Hahn, Andreas
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|
dc.date.accessioned |
2018-01-29T14:13:19Z |
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dc.date.available |
2018-01-29T14:13:19Z |
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dc.date.issued |
2003 |
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dc.identifier.citation |
Breithaupt, D.E.; Weller, P.; Wolters, M.; Hahn, A.: Plasma response to a single dose of dietary βcryptoxanthin esters from papaya (Carica papaya L.) or non-esterified β-cryptoxanthin in adult human subjects: A comparative study. In: British Journal of Nutrition 90 (2003), Nr. 4, S. 795-801. DOI: https://doi.org/10.1079/BJN2003962 |
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dc.description.abstract |
Many orange-coloured fruits contain β-cryptoxanthin in its non-esterified as well as its esterified form. Information concerning the absorption of β-cryptoxanthin, especially with regard to the metabolism of its fatty acid esters, is rather scarce. The present study assessed the plasma concentration reached after consumption of a single dose of native β-cryptoxanthin esters from papaya (Carica papaya L.) or non-esterified β-cryptoxanthin in equal total amounts. In a randomized, single-blind crossover study, twelve subjects were served a portion of yoghurt containing esterified or non-esterified β-cryptoxanthin (1.3 mg absolute) together with a balanced breakfast. Between the two intervention days, there was a 2-week depletion period. After a fasting blood sample had been taken, futher samples were taken from the subjects at 3, 6, 9, 12 and 24 h. The concentration of non-esterified β-cryptoxanthin in the whole plasma was determined by HPLC; β-cryptoxanthin identification was confirmed by liquid chromatography-atmospheric pressure chemical ionization-MS analyses. Irrespective of the consumed diet, the plasma β-cryptoxanthin concentrations increased significantly (P=0.05) and peaked after 6-12h. The concentration curves, as well as the areas under the curves, were not distinguishable according to two-sided F and t tests (P=0.05). Standardization of β-cryptoxanthin concentrations to plasma triacylglycerol and cholesterol had no impact on the results. Thus, the present study indicates comparable bioavailability of both non-esterified β-cryptoxanthin and mixtures of β-cryptoxanthin esters. The results support the existence of an effective enzymatic cleavage system accepting various p-cryptoxanthin esters. |
eng |
dc.language.iso |
eng |
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dc.publisher |
Cambridge : Cambridge University Press |
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dc.relation.ispartofseries |
British Journal of Nutrition 90 (2003), Nr. 4 |
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dc.rights |
Es gilt deutsches Urheberrecht. Das Dokument darf zum eigenen Gebrauch kostenfrei genutzt, aber nicht im Internet bereitgestellt oder an Außenstehende weitergegeben werden. Dieser Beitrag ist aufgrund einer (DFG-geförderten) Allianz- bzw. Nationallizenz frei zugänglich. |
|
dc.subject |
β-Cryptoxanthin |
eng |
dc.subject |
Carotenoid ester |
eng |
dc.subject |
Liquid chromatography-atmospheric pressure chemical ionization-mass spectroscopy |
eng |
dc.subject |
Plasma carotenoid response |
eng |
dc.subject |
beta cryptoxanthin |
eng |
dc.subject |
cholesterol |
eng |
dc.subject |
cryptoxanthin |
eng |
dc.subject |
ester |
eng |
dc.subject |
triacylglycerol |
eng |
dc.subject |
unclassified drug |
eng |
dc.subject |
yoghurt |
eng |
dc.subject |
antineoplastic agent |
eng |
dc.subject |
beta carotene |
eng |
dc.subject |
cholesterol |
eng |
dc.subject |
cryptoxanthin |
eng |
dc.subject |
drug derivative |
eng |
dc.subject |
triacylglycerol |
eng |
dc.subject |
xanthophyll |
eng |
dc.subject |
adult |
eng |
dc.subject |
area under the curve |
eng |
dc.subject |
article |
eng |
dc.subject |
bioavailability |
eng |
dc.subject |
blood level |
eng |
dc.subject |
blood sampling |
eng |
dc.subject |
cholesterol blood level |
eng |
dc.subject |
clinical article |
eng |
dc.subject |
clinical trial |
eng |
dc.subject |
comparative study |
eng |
dc.subject |
controlled clinical trial |
eng |
dc.subject |
controlled study |
eng |
dc.subject |
crossover procedure |
eng |
dc.subject |
diet restriction |
eng |
dc.subject |
dietary intake |
eng |
dc.subject |
esterification |
eng |
dc.subject |
female |
eng |
dc.subject |
high performance liquid chromatography |
eng |
dc.subject |
human |
eng |
dc.subject |
human experiment |
eng |
dc.subject |
male |
eng |
dc.subject |
mass spectrometry |
eng |
dc.subject |
meal |
eng |
dc.subject |
normal human |
eng |
dc.subject |
papaya |
eng |
dc.subject |
randomized controlled trial |
eng |
dc.subject |
single blind procedure |
eng |
dc.subject |
standardization |
eng |
dc.subject |
triacylglycerol blood level |
eng |
dc.subject |
blood |
eng |
dc.subject |
chemistry |
eng |
dc.subject |
diet supplementation |
eng |
dc.subject |
intestine absorption |
eng |
dc.subject |
methodology |
eng |
dc.subject |
papaya |
eng |
dc.subject |
Carica |
eng |
dc.subject |
Carica papaya |
eng |
dc.subject |
Adult |
eng |
dc.subject |
Anticarcinogenic Agents |
eng |
dc.subject |
beta Carotene |
eng |
dc.subject |
Carica |
eng |
dc.subject |
Cholesterol |
eng |
dc.subject |
Chromatography, High Pressure Liquid |
eng |
dc.subject |
Cross-Over Studies |
eng |
dc.subject |
Dietary Supplements |
eng |
dc.subject |
Esters |
eng |
dc.subject |
Female |
eng |
dc.subject |
Humans |
eng |
dc.subject |
Intestinal Absorption |
eng |
dc.subject |
Male |
eng |
dc.subject |
Single-Blind Method |
eng |
dc.subject |
Triglycerides |
eng |
dc.subject |
Xanthophylls |
eng |
dc.subject |
Yogurt |
eng |
dc.subject.ddc |
610 | Medizin, Gesundheit
|
ger |
dc.title |
Plasma response to a single dose of dietary βcryptoxanthin esters from papaya (Carica papaya L.) or non-esterified β-cryptoxanthin in adult human subjects: A comparative study |
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dc.type |
Article |
|
dc.type |
Text |
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dc.relation.issn |
0007-1145 |
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dc.relation.doi |
https://doi.org/10.1079/BJN2003962 |
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dc.bibliographicCitation.issue |
4 |
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dc.bibliographicCitation.volume |
90 |
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dc.bibliographicCitation.firstPage |
795 |
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dc.bibliographicCitation.lastPage |
801 |
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dc.description.version |
publishedVersion |
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tib.accessRights |
frei zug�nglich |
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