Zusammenfassung: | |
Many orange-coloured fruits contain β-cryptoxanthin in its non-esterified as well as its esterified form. Information concerning the absorption of β-cryptoxanthin, especially with regard to the metabolism of its fatty acid esters, is rather scarce. The present study assessed the plasma concentration reached after consumption of a single dose of native β-cryptoxanthin esters from papaya (Carica papaya L.) or non-esterified β-cryptoxanthin in equal total amounts. In a randomized, single-blind crossover study, twelve subjects were served a portion of yoghurt containing esterified or non-esterified β-cryptoxanthin (1.3 mg absolute) together with a balanced breakfast. Between the two intervention days, there was a 2-week depletion period. After a fasting blood sample had been taken, futher samples were taken from the subjects at 3, 6, 9, 12 and 24 h. The concentration of non-esterified β-cryptoxanthin in the whole plasma was determined by HPLC; β-cryptoxanthin identification was confirmed by liquid chromatography-atmospheric pressure chemical ionization-MS analyses. Irrespective of the consumed diet, the plasma β-cryptoxanthin concentrations increased significantly (P=0.05) and peaked after 6-12h. The concentration curves, as well as the areas under the curves, were not distinguishable according to two-sided F and t tests (P=0.05). Standardization of β-cryptoxanthin concentrations to plasma triacylglycerol and cholesterol had no impact on the results. Thus, the present study indicates comparable bioavailability of both non-esterified β-cryptoxanthin and mixtures of β-cryptoxanthin esters. The results support the existence of an effective enzymatic cleavage system accepting various p-cryptoxanthin esters.
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Lizenzbestimmungen: | Es gilt deutsches Urheberrecht. Das Dokument darf zum eigenen Gebrauch kostenfrei genutzt, aber nicht im Internet bereitgestellt oder an Außenstehende weitergegeben werden. Dieser Beitrag ist aufgrund einer (DFG-geförderten) Allianz- bzw. Nationallizenz frei zugänglich. |
Publikationstyp: | Article |
Publikationsstatus: | publishedVersion |
Erstveröffentlichung: | 2003 |
Schlagwörter (englisch): | β-Cryptoxanthin, Carotenoid ester, Liquid chromatography-atmospheric pressure chemical ionization-mass spectroscopy, Plasma carotenoid response, beta cryptoxanthin, cholesterol, cryptoxanthin, ester, triacylglycerol, unclassified drug, yoghurt, antineoplastic agent, beta carotene, cholesterol, cryptoxanthin, drug derivative, triacylglycerol, xanthophyll, adult, area under the curve, article, bioavailability, blood level, blood sampling, cholesterol blood level, clinical article, clinical trial, comparative study, controlled clinical trial, controlled study, crossover procedure, diet restriction, dietary intake, esterification, female, high performance liquid chromatography, human, human experiment, male, mass spectrometry, meal, normal human, papaya, randomized controlled trial, single blind procedure, standardization, triacylglycerol blood level, blood, chemistry, diet supplementation, intestine absorption, methodology, papaya, Carica, Carica papaya, Adult, Anticarcinogenic Agents, beta Carotene, Carica, Cholesterol, Chromatography, High Pressure Liquid, Cross-Over Studies, Dietary Supplements, Esters, Female, Humans, Intestinal Absorption, Male, Single-Blind Method, Triglycerides, Xanthophylls, Yogurt |
Fachliche Zuordnung (DDC): | 610 | Medizin, Gesundheit |
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