Browsing Naturwissenschaftliche Fakultät by Subject "AAA+ ATPase"

Browsing Naturwissenschaftliche Fakultät by Subject "AAA+ ATPase"

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  • Dissecting the Mechanism of Protein Unfolding by the Unfoldase PAN using Structural Biology 
    Krüger, Georg Ernst Heinrich (Hannover : Institutionelles Repositorium der Leibniz Universität Hannover, 2021)
    The proteasome as the major cellular protease plays a central role in regulated protein deg-radation in all kingdoms of life. Besides the proteolytic core particle, the proteasome com-prises an ATP-dependent unfoldase ...
  • An NMR Study of a 300-kDa AAA+ Unfoldase 
    Krüger, Georg; Kirkpatrick, John; Mahieu, Emilie; Franzetti, Bruno; Gabel, Frank; Carlomagno, Teresa (Amsterdam [u.a.] : Elsevier, 2023)
    AAA+ ATPases are ubiquitous hexameric unfoldases acting in cellular protein quality control. In complex with proteases, they form protein degradation machinery (the proteasome) in both archaea and eukaryotes. Here, we use ...
  • A real-time analysis of GFP unfolding by the AAA+ unfoldase PAN 
    Krüger, Georg; Kirkpatrick, John; Mahieu, Emilie; Franzetti, Bruno; Gabel, Frank; Carlomagno, Teresa (Amsterdam [u.a.] : Elsevier, 2023)
    Protein quality control systems are essential to maintain a healthy proteome. They often consist of an unfoldase unit, typically an AAA+ ATPase, coupled with a protease unit. In all kingdoms of life, they function to ...

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