Browsing by Subject "PD-1"

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1H, 13C, 15N chemical shift assignments of SHP2 SH2 domains in complex with PD-1 immune-tyrosine motifs

Marasco, Michelangelo; Kirkpatrick, John P.; Carlomagno, Teresa (Dordrecht [u.a.] : Springer Netherlands, 2020)

Inhibition of immune checkpoint receptor Programmed Death-1 (PD-1) via monoclonal antibodies is an established anticancer immunotherapeutic approach. This treatment has been largely successful; however, its high cost demands ...
Phosphotyrosine couples peptide binding and SHP2 activation via a dynamic allosteric network

Marasco, Michelangelo; Kirkpatrick, John; Nanna, Vittoria; Sikorska, Justyna; Carlomagno, Teresa (Gotenburg : Research Network of Computational and Structural Biotechnology (RNCSB), 2021)

SHP2 is a ubiquitous protein tyrosine phosphatase, whose activity is regulated by phosphotyrosine (pY)-containing peptides generated in response to extracellular stimuli. Its crystal structure reveals a closed, auto-inhibited ...

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