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Ablation of Red Stable Transfected Claudin Expressing Canine Prostate Adenocarcinoma and Transitional Cell Carcinoma Cell Lines by C-CPE Gold-Nanoparticle-Mediated Laser Intervention

Alnajjar, Suhayla; Nolte, Ingo; Becker, Annegret; Schille, Jan Torben; Trakooljul, Nares; Frank, Marcus; Ngezahayo, Anaclet; Murua Escobar, Hugo (Basel : Molecular Diversity Preservation International (MDPI), 2021)

Claudin (CLDN) proteins are commonly expressed in cancers and targeted in novel therapeutic approaches. The C-terminal of Clostridium perfringens enterotoxin (C-CPE) efficiently binds several claudins. In this study, ...
Functionalization of gold-nanoparticles by the Clostridium perfringens enterotoxin C-terminus for tumor cell ablation using the gold nanoparticle-mediated laser perforation technique

Becker, Annegret; Leskau, Miriam; Schlingmann-Molina, Barbara L.; Hohmeier, Susanne C.; Alnajjar, Suhayla; Escobar, Hugo Murua; Ngezahayo, Anaclet (London : Nature Publishing Group, 2018)

A recombinant produced C-terminus of the C. perfringens enterotoxin (C-CPE) was conjugated to gold nanoparticles (AuNPs) to produce a C-CPE-AuNP complex (C-CPE-AuNP). By binding to claudins, the C- CPE should allow to ...
Parameters for optoperforation-induced killing of cancer cells using gold nanoparticles functionalized with the c-terminal fragment of Clostridium Perfringens enterotoxin

Becker, Annegret; Lehrich, Tina; Kalies, Stefan; Heisterkamp, Alexander; Ngezahayo, Anaclet (Basel : MDPI AG, 2019)

Recently, we used a recombinant produced C-terminus (D194-F319) of the Clostridium perfringens enterotoxin (C-CPE) to functionalize gold nanoparticles (AuNPs) for a subsequent specific killing of claudin expressing tumor ...
Probing Ligand-Receptor Interaction in Living Cells Using Force Measurements With Optical Tweezers

Riesenberg, Carolin; Iriarte-Valdez, Christian Alejandro; Becker, Annegret; Dienerowitz, Maria; Heisterkamp, Alexander; Ngezahayo, Anaclet; Torres-Mapa, Maria Leilani (Lausanne : Frontiers Media, 2020)

This work probes the binding kinetics of COOH-terminus of Clostridium perfringens enterotoxin (c-CPE) and claudin expressing MCF-7 cells using force spectroscopy with optical tweezers. c-CPE is of high biomedical interest ...
Tight Junction-bindendes C-terminales Clostridium perfringens Enterotoxin für Goldnanopartikel-vermittelte Optoperforation von Zellen : neue Methode für die Krebstherapie

Becker, Annegret (Hannover : Institutionelles Repositorium der Leibniz Universität Hannover, 2019)

Tight Junctions sind apikale interzelluläre Proteinverbindungen zwischen Epithelzellen. Die Überexpression von bestimmten Proteinen der Tight Junctions wie z.B. Claudin-3, -4 und -7 ist für einige Krebsarten charakteristisch. ...

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